摘要
背景与目的中晚期肺癌治疗效果欠佳,CIK过继免疫疗法作为治疗非小细胞肺癌的一种辅助疗法日益受到重视。本研究通过比较支气管动脉灌注化疗、全身化疗和支气管动脉灌注联合CIK细胞过继免疫治疗Ⅲ期非小细胞肺癌,探讨支气管动脉灌注联合CIK细胞过继免疫治疗中晚期非小细胞肺癌的可行性。方法选取120例Ⅲ期非小细胞肺癌病例,随机分为支气管动脉灌注化疗组、全身化疗组和支气管动脉灌注化疗联合CIK细胞过继免疫治疗组,行2周期治疗后,评价临床疗效和毒副作用。结果支气管动脉灌注化疗联合CIK细胞治疗组的临床有效率(CR+PR%)高于全身化疗组(66.67%,n=39),差异有统计学意义(χ2=4.721,P=0.03);骨髓抑制毒性和非骨髓抑制毒性发生率低于全身化疗组(P<0.05),差异有统计学意义。单纯支气管动脉灌注化疗组肿瘤进展率(PD%)高于支气管动脉灌注化疗联合CIK组(χ2=4.287,P=0.038),差异有统计学意义。全身化疗组和支气管动脉灌注化疗联合CIK组之间比较肿瘤进展率(PD%)无统计学差异(χ2=0.082,P=0.775)。结论支气管动脉灌注化疗联合CIK过继免疫治疗非小细胞肺癌,在控制肺内原发灶方面疗效优于全身化疗;在控制和预防远处转移方面与全身化疗无差异,是一种较为理想、安全有效的综合性治疗手段,值得推广应用。
Background and objective The therapeutic efficacy of late lung-cancer was very poor, and cytokine-induced killer cells （CIK） were paid more attention to treat non-small cell lung cancer （NSCLC）. The aim of this study is to get insight into the role of bronchial arterial infusion bronchial arterial infusion （BM） plus CIK about NSCLC by comparing therapeutic efficacy among BAI, traditional vein chemotherapy and BM plus CIK, for late NSCLC. Methods A total of 120 patients were enrolled in this study, dividing randomly into three groups： bronchial arterial infusion （BAI）, traditional vein chemotherapy and BAI plus CIK. Clinical effects and side effects were estimated after two period of therapy. Results The effective rate （CR＋PR%） of combined group is higher than the traditional vein chemotherapy group （66.67%, n=39） and there are significant differences （Χ^2=4.721, P=0.03）; The side effect of rate of BAI plus CIK group is significantly lower than the traditional vein chemotherapy group, and so did the non-bone marrow inhibition side effects （P〈0.05）. The tumor progression rate （PD%） of bronchial arterial infusion （BAd） group is higher than combined group （Χ^2=4.287, P=0.038）. There was no difference between the traditional vein chemotherapy group and combined group （Χ^2=0.082, P=0.775）. Conclusion Bronchial Artery Infusion combined with cytokine-induced killer cells is an ideal, safety, effective comprehensive treatment method for late stage lung cancer.
出处
《中国肺癌杂志》
CAS
2009年第9期1000-1004,共5页
Chinese Journal of Lung Cancer
基金
云南省科技创新强省国际合作专项基金(No.2008CA030)
云南省教育厅基金(No.06y113c)项目资助~~
关键词
肺肿瘤
支气管动脉灌注
CIK细胞
化疗
Lung neoplasms
Bronchial arterialinfusion
Cytokine-induced killer cells
Chemotherapy
