摘要
目的:探讨冠心病患者血浆可溶性OX40配体(sOX40L)和巨噬细胞移动抑制因子(MIF)与冠状动脉病变程度的关系。方法:68例冠心病患者包括急性心肌梗死(AMI)14例,不稳定型心绞痛(UAP)37例,稳定型心绞痛(SAP)17例;行冠脉造影判定冠状动脉病变程度,单支病变26例,双支病变24例,三支病变18例。20例冠状动脉造影结果正常者为对照组。采用ELISA法测定血浆sOX40L和MIF水平。结果:4组sOX40L和MIF水平差异有统计学意义(F分别为2.82,3.05,P均<0.05)。AMI和UAP组血浆sOX40L和MIF水平高于SAP组和对照组(P<0.05),而SAP组与对照组之间差异无统计学意义(P>0.05)。不同冠脉病变程度组sOX40L和MIF水平差异有统计学意义(F分别为2.78,2.93,P均<0.05)。单支、双支、三支病变组血浆sOX40L和MIF水平均高于对照组(P<0.05),但单支、双支与三支病变组间差异均无统计学意义(P>0.05)。AMI组、UAP组患者血浆sOX40L和MIF水平正相关(r分别为0.624,0.637,P均<0.05),SAP组、对照组患者sOX40L和MIF水平无相关性(P>0.05)。结论:血浆sOX40L和MIF可作为预测斑块稳定性的标志物,为冠心病危险分层及采取积极干预措施提供依据,但不能反映冠状动脉狭窄程度及范围。
Aim：To investigate the relationship between plasma soluble OX40 ligend（sOX40L）,macrophage migration inhibitory factor（MIF） level and the severity of coronary lesions in patients with coronary heart disease（CHD）.Methods：A total of 68 patients with CHD,including 14 cases of acute myocardial infarction（AMI）,37 cases of angina pectoris（UAP） and 17 cases of angina pectoris（SAP）,and 20 normal subjects without CHD diagnosed by CAG served as the control group,were subjected to detect the plasma levels of sOX40L and MIF by ELISA. Among the 68 cases,the number of patients with single, double and three vessel lesion diagnosed by CAG were 26,24,18. Results： The plasma levels of sOX40L and MIF in AMI, UAP, SAP, and the control group were different（ F = 2.82,3.05, P 〈 0.05 ）. Those in AMI and UAP group were higher than those in SAP group and control group（ P 〈 0.05 ）. The plasma levels of sOX40L and MIF in SAP group did not differ significantly from those in control group（P 〉 0.05 ）. The plasma levels of sOX40L and MIF in single, double and three vessel lesion group were higher than those in control group（ P 〈 0.05 ） , but the plasma levels of sOX40L and MIF among single, double and three vessel lesion group were not significant different（P 〉 0.05 ）. A significant positive correlation was found between the plasma levels of sOX40L and MIF in AMI, UAP group（ r =0. 624,0. 637, P 〈 0.05 ） , no correlation was found in SAP group and control group. Conclusion ： sOX40L and MIF may act as the biomarkers of vulnerable plaques, and take active action to stabilize vulnerable plaques and decrease the occurrence of cardiac events, but may not reflect the severity of artery stenosis.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2009年第4期742-744,共3页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省杰出青年科学基金资助项目094100510017
