摘要
目的探讨巨噬细胞移动抑制因子(MIF)和基质金属蛋白酶-1(MMP-1)在急性冠脉综合征(ACS)患者血清中的变化及其临床意义。方法将120例冠心病患者分为3组:急性心肌梗死(AMI)组38例、不稳定性心绞痛(UAP)组42例和稳定性心绞痛(SAP)组40例,另选同期30例冠状动脉造影正常者为对照组。采用酶联免疫吸附法(ELISA)测定血清MIF、MMP-9水平。结果 AMI组、UAP组血清MIF、MMP-水平均显著高于SAP组及对照组(P<0.05),ACS患者血清MIF与MMP-1水平呈正相关(r=0.83,P<0.01)。结论 ACS患者血清MIF、MMP-1水平明显增高,可作为ACS发病的重要预测因子。
Objective To explore change of serum levels of macrophage migration inhibitory factor（MIF） and matrix metalloproteinase -9（MMP - 1） and their clinical value in acute coronary syndrome（ACS）.Methods 120 patients with coronary heart disease were divided into three groups：acute myocardial infarction（AMI） group（n =38）,unstable angina pectoris（UAP） group（n =42） and stable angina pectoris（SAP） group（n =40）.30 people with normal coronary angiography were selected as control group.The serum concentrations of MIF and MMP - 1 were detected by ELISA. Results The concentrations of MIF and MMP - 1 in AMI group and UAP group were significantly higher than those in SAP and control group（P0.05）.The concentrations of MIF was positively correlated with MMP - 1 significantly in ACS patients （r = 0.83,P0.01）.Conclusion The concentrations of MIF and MMP - 1 were significantly increased in patients with ACS,which may be important in prediction of ACS.
出处
《南华大学学报（医学版）》
2010年第6期784-785,788,共3页
Journal of Nanhua University(Medical Edition)
