摘要
目的:探讨何首乌饮对衰老大鼠肾脏TGF-β1和TIMP-1表达的影响。方法:D-半乳糖腹腔注射法建立大鼠衰老模型,并给予何首乌饮连续灌胃。采用免疫组织化学方法观察肾脏TGF-β1和TIMP-1的表达。结果:何首乌饮组大鼠肾脏TGF-β1和TIMP-1蛋白的表达明显低于模型组(P<0.01,P<0.05)。结论:何首乌饮能改善肾小球硬化和肾间质纤维化,具有延缓肾脏衰老的作用。
Objective：To investigate the effects of HESHOUWUYIN on expression of TGF- β1 and TIMP-1 in senile rat＇s kidney.Methods：The senile rats model was made by abdominal injecting D-galactose and oral administration of HESHOUWUYIN. SP immunohistochemistry was used to observe expression of TGF-β1 and TIMP-1 in kidney.Results：The expression of TGF- β1 and TIMP-1 in kidney of rats in HESHOUWUYIN group were obviously lower than model group （P〈0.01,P〈0.05）.Conclusions：HESHOUWUYIN can improve glomerulosclerosis and renal interstitial fibrosis, so has anti-aging effects on kidney of senile rats.
出处
《承德医学院学报》
2009年第3期248-250,F0002,共4页
Journal of Chengde Medical University
