摘要
用肾综合症出血热病毒感染的乳鼠致病模型，将病毒唑经口服和皮下注射给药治疗病毒感染鼠。结果口服给药组两种剂量动物存活率和平均存活时间无差异，注射给药组差异显著。动物体内病毒抗原含量在两种给药途径组无差异，但在注射给药组有剂量差异。口服给药可降低病毒唑毒副作用。
Using hemorrhagic fever with renal syndrome (HFRS) pattern in suckling mice infected with Hantanvirus, ribvirin was given by subcutaneously and oral routes. The results showed that the survival rate and means time day had no difference in two dosages in oral administration group, but the difference was significant in injection administration group. The viral antigen amount had no difference in different route of administration, but the difference was significant in two dosages in injectous administration. The results indicated that the toxicity and side-effect of ribavirin can be decreased by oral administration.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1998年第3期145-147,共3页
West China Journal of Pharmaceutical Sciences
