摘要
目的:探讨四逆汤含药血清抗心肌毒性的疗效及其作用机制。方法:采用盐酸阿霉素(ADR)损伤W istar大鼠乳鼠心肌导致心肌毒性为模型。随机分为正常组、心脏毒性ADR模型对照组、卡托普利组、四逆汤含药血清组.测定大鼠乳鼠血清Bc l-2、Bax水平,并应用光镜观察心肌组织的病理变化。结果:与正常组比较,阿霉素致心肌毒性大鼠乳鼠血清Bax水平显著降低,血清Bc l-2水平明显升高,四逆汤及卡托普利均能降低Bc l-2水平,升高Bax水平(P<0.05)。光镜显示,四逆汤含药血清治疗组心肌细胞损伤程度明显低于模型组。结论:四逆汤含药血清能调节改善心肌毒性大鼠乳鼠的神经内分泌功能,拮抗过度激活的神经内分泌系统。
Objective：To explore the clinical effect and machenism of blood serum of decoction for treating yang exhaustion on adriamycin induced cardio-toxieity in myocardial cell. Methods ： Wistar rats were used to make cardio-toxieity in myocardial cell of rat model by injection of adriamyc into the peritoneum. The other 10 Wistar rats were divided into the normal group. Model rats were randomly divided into model control group. Captopril group and blood serum of decoction for treating yang exhaustion group. Results ： Compared with the normal group, serum baxlevel significantly decreased and Bcl -2level significantly increased. Compared with the model failure group, serum Bcl -2level significantly decreased and the level of baxsignifieantly increased in the blood serum of decoction for treating yang exhaustion group and the Captopril group（ P 〈 0. 05 ）. The degree of mycardial damage in the blood serum of decoction for treating yang exhaustion group was obviously lower than that in the model group. Conclusion ： Blood serum of decoction for treating yang exhaustion can modify the nerval endocrine function of eardio - toxicity in myocardial cell failure rat and can antagonize the hyperactive nerval endocrine system.
出处
《中华中医药学刊》
CAS
2009年第8期1684-1686,共3页
Chinese Archives of Traditional Chinese Medicine
基金
黑龙江省教育厅科学技术研究资助项目(11531430)
关键词
四逆汤含药血清
心肌毒性
BAX
blood serum of decoction for treating yang exhaustion
cardio-toxicity
Bax
