摘要
目的探讨阿维A联合糖皮质激素治疗重症银屑病的临床疗效和安全性。方法59例重症银屑病患者随机分成两组:治疗组(n=31):应用阿维A联合糖皮质激素治疗,先口服强的松1mg/(kg·d)或静脉滴注地塞米松7.5～12.5mg/d,治疗1～2周后,加口服阿维A0.3～0.5mg/(kg·d);对照组(n=28):单纯口服阿维A胶囊进行治疗。结果治疗组和对照组有效率分别为87.10%和64.29%,差异有统计学意义(P<0.05),两组均未发生严重不良反应。结论阿维A联合糖皮质激素治疗重症银屑病是一种安全有效的方法。
[Objective] To explore the clinical effect and security of aeitretin capsules combined with glucocorticold in the treatment of severe psoriasis. [Methods] 59 patients with severe psoriasis were randomly divided into two groups： experiment group and control group. In experiment group, 31 patients were treated with aeitretin capsules and glucocorticoid. The course of treatment included 1 mg prednisone per kilogram of body weight by oral administration per day or 7.5-12.5 mg dexamethasone by intravenous drip per day and 0.3-0.5 mg aeitrefin capsules per kilogram of body weight by oral administration per day. In control group, 28 patients were treated with acitretin capsules only according to 0.3-0.5 mg aeitretin capsules per kilogram of body weight by oral administration per day. [Results] The total effective rates in experiment group and control group were 87.10% and 64.29%, respectively. The significant difference existed between the two groups statistically in the effective rate （P 〈0.05）. No severe adverse reaction occurred in any group. [Conclusion] Aeitretin capsules combined with glucocortieoid is a safe and effective therapeutic method for severe psoriasis.
出处
《中国医学工程》
2009年第2期109-111,共3页
China Medical Engineering
关键词
重症银屑病
阿维A
糖皮质激素
临床疗效
severe psoriasis
acitretin capsules
glucocorticoid
clinical effect
