摘要
目的:研究影响山红调脂滴丸制备工艺的各种因素,确立最佳制备工艺。方法:采用正交设计试验方法,以溶散时限、圆整度为指标确定滴丸的处方工艺,以丸重合格率为指标筛选滴丸滴制条件。结果:最佳工艺为滴制温度为85℃,PEG4000与PEG6000比例为1∶1,药物与基质的比例为1∶5,冷却温度10℃,滴距10cm,滴速20～30滴/min。结论:制得的滴丸溶散时限、圆整度及丸重均符合质量要求,该工艺合理、简便。
Objective： To establish the best preparation technology of Shanhongtiaozhi dripping pills. Method： Time of dissolution, spherical degree and pill weight were used as parameters, and the influential factors were investigated by orthogonal test. Result： The optimum conditions were as follows ： the weight proportion of PEG4000 and PEG6000 was 1 ： 1, the weight proportion of extracting substance and matrix was 1：5, the dripping temperature was 85℃, dripping distance was 10cm, the temperature of refrigerant was 10℃, the rate of dripping was 20 - 30 drips per minute. Conclusion： The time of dissolution, spherical degree and weight of pills are all conformable to the guality reguirement and the technology is reasoneble, simple and convenient.
出处
《中国药师》
CAS
2009年第7期850-852,共3页
China Pharmacist
基金
广东省中医药管理局项目(编号:2007164)
关键词
山楂叶
红曲
滴丸
成型工艺
Hawthorn leaves
Red yeast rice
Dropping pill
Preparation technology
