摘要
目的探讨促性腺激素释放激素(GnRH)拮抗剂在卵巢反应不良患者中的应用。方法对既往应用体外受精-胚胎移植(IVF-ET)技术治疗过程中发生卵巢反应不良或取消周期的60例不孕患者随机对照分为两组,GnRH拮抗剂组和GnRH激动剂方案组,观察激素水平、获卵数、受精率、妊娠率等。结果拮抗剂组获卵数多于激动剂组(3.36±1.97 vs 2.43±0.92,P=0.038),两组患者在HCG日LH水平、E2水平和P水平没有明显差异,在>14mm的卵泡数、妊娠率分别为(3.04±1.33 vs 2.73±0.87,P=0.082)、(24%vs 14.3%,P=0.291),两组患者均没有出现LH峰值。结论GnRH拮抗剂方案对卵巢反应不良的患者不失为可尝试的治疗方法。
Objective ： To compare the effect of gonadotropin - releasing hormone antagonist with gonadotropin - releasing hormone agonist on the patients with histories of poor ovarian response or being cancelled. Design ： Prospective study. Setting： University hospital. Methods ： 60 women with histories of poor ovarian response and being cancelled were divided into group A, who received gonadotropin - releasing hormone antagonist （ n =29 ）, and group B, who adopted with gonadotropin - releasing hormone agonist （ n = 31 ）. Main Outcome Measure （s） ： Oocytes retrieved, serum LH and estradiol levels, maturity of oocytes, fertilization rates, embryo number and quality, and pregnancy rates （PR）. Results： 53 patients completed follicle aspirations. No LH surges occurred in two groups. The patients got more oocytes in group A than group B. There are no significant difference in mature follicles, fertilization rate, pregnancy rate and abortion rates, 6 of 25 patients resulted in a clinical pregnancy （24% PR per retrieval） in group A and 4 of 28 patients got pregnancy in group B （14. 3% ）. Conclusion： A gonadotropin -releasing hormone antagonist multiple protocol may be the better choice for the treatment of poor ovarian response.
出处
《中国优生与遗传杂志》
2009年第4期118-120,共3页
Chinese Journal of Birth Health & Heredity
