摘要
目的研究奥尔芬-75、杜冷厂和盐酸曲马多对肾绞痛的镇痛效果,评价奥尔芬-75治疗肾绞痛的可行性。方法108例肾绞痛患者随机分为奥尔芬-75(甲,n=36)组、杜冷丁(丙,n=36)和盐酸曲马多(丙,n=36)组,分别给予奥尔芬-75、杜冷丁和盐酸曲马多镇痛。采用VRSs-4和NRS分析3种药物的镇痛效果,同时观察药物不良反应。结果甲组和乙组镇痛效果和起效时间优于丙组(P<0.05),甲与乙组无差异;但甲组持续时间和不良反应优于乙组和丙组(P<0.01)。结论奥尔芬-75对肾绞痛镇痛效果与杜冷丁无差异、但优于曲马多;奥尔芬-75镇痛持续时间和不良反应优于杜冷丁、且无成瘾性,对肾绞痛临床疗效优点杜冷丁和曲马多,值得提倡使用。
OBJECTIVE To compare the efficacy and adverse effects of intramuscular olfen-75 and intramuscular dolantin, or Tramadol hydrochloride in the relief of acute renal colic. METHODS Randomized study was performed in 108 patients admitted to the emergency room for renal colic. Patients were assigned to treatment with either Olfen-75 （A group） 75mg or dolantin （B group） 50-100mg, or tramadol （C group） 100mg, all administered intramuscularly. Pain was self-assessed using a 4-point verbal rating scale （VRS-4） and a Numeric rating scale （NRS） just before drug administration and 15, 30, 60,120,240,360 and 480 minutes later. RESULTS The 3 groups were similar with regard to baseline characteristics. The percentages of patients who reported an improvement in the VRS at 60 rain post-administration （primary variable） at A and B groups versus C group were significant （P = 0. 001 ） ; between A and B groups were no siginificant （P 〉 0.05）. The NRS score showed a statistically significant improvement in theree groups, but no differences between A and B groups were found. But the time of renal colic relief in A group showed significant （P 〈 0.01 ） longer than B and C groups. Mild to moderate adverse events were reported by 14 frequency of patients receiving Oleen-75 and by 40 frequency of patients receiving dolantin, and by 36 frequency patients receiving tramadol. CONCLUSIONS Olfen-75 was similarly effective in the relief of acute renal colic as dolatin, but better than tramadol hydrochloride, and at the same time, mild to moderate adverse events of Olfen-75 were less than dolantin and tramadol hydrochloride.
出处
《海峡药学》
2009年第1期102-104,共3页
Strait Pharmaceutical Journal
