摘要
Insulin resistance is simply the in- ability of insulin to elicit a physiologic response. While insulin resistance is most commonly associated with the pathogenesis of metabolic disorders such as type Ⅱ diabetes and obesity, it is also a predisposing factor to a number of other diseases such as cancer and cardiovascular disease [1]. There are just as many theories as to the cause of insulin resistance as there are insulin signaling molecules and it is very unclear as to which are the actual molecular mechanisms of insulin resistance in diseased states. In a recent paper Luan and colleagues present a novel finding that down-regulation of the β-arrestin 2 signaling molecule in insulin resistant/ diabetic mice and humans may be an underlying cause [2].
