摘要
目的研究血清中的大肠癌特异性抗原CCSA-2在大肠癌诊断中的作用.方法采集135例病人血清,使用间接ELISA法检测血清中CCSA-2浓度.结果运用ROC曲线来衡量CCSA-2的敏感性和特异性.CCSA-2,在截止的10.8μg/mL总体上的95.9%的敏感性(95%CI,96.4%～99.9%)和89.5%的特异性(95%CI为,78.3.3%～91.7%),ROC曲线中CCSA-2在诊断进展期腺癌和大肠癌与其他血清样本曲线下面积为0.981(95%CI,0.83%～0.95%;P<0.01);ROC曲线中CCSA-2在区别较大的息肉(进展期腺瘤)对那些较小的息肉(非进展期腺瘤)的曲线下面积0.89(95%CI,0.78%～0.92%).结论CCSA-2是一个潜在的检测直结肠癌具有高敏感性和特异性的血清型标记物.
Objective To explore the role of colon cancer-specific antigen 2 in diagnosis of colorectal cancer.Methods 135 serum samples were collected from patients, we used an indirect ELISA on serum samples to detect the density of CCSA-2.Results Receiver operating characteristic analysis were used to measure the sensitivity and specificity of CCSA-2.CCSA-2 at a cutoff of 10.8 μg/mL had overall sensitivity of 95.9% [95% confidence interval （95% C）I,96.4%～99.9%] and specificity of 89.5% （95% CI,78.33% ～91.7%） in separatingindividuals with advanced adenomas and colorectal cancer fromnormal,hyperplastic, and nonadvanced adenoma populations.The receiver operating characteristic curve for CCSA-2 had an area under the curve of 0.981 （95% CI,0.83%～0.95%;P 〈 0.01）;ROC analysis of CCSA-2 in individuals with larger polyps （advanced adenomas） versus those with smaller polyps （nonadvanced adenomas） showed an area under the curve of 0.89 （95% CI,0.78%～0.92%）.Conclusion Colon cancer -specific antigen 2 is a high sensitive and specific serum marker for colorectal cancer
出处
《昆明医学院学报》
2009年第1期88-90,99,共4页
Journal of Kunming Medical College
关键词
大肠癌
肿瘤标志物
ELISA
ROC曲线
Colorectal cancer
Tumor marker
ELISA
Receiver operating characteristic analysis
