摘要
目的研究大肠癌患者血清中多种肿瘤蛋白标志物的改变情况及联合检测在诊断中的价值。方法采用C12多种肿瘤标志物蛋白芯片检测系统测定139例大肠癌患者和63例大肠良性病变患者血清中12种肿瘤标志物(CA199,NSE,CEA,CA242,CA125,CA153,AFP,ferritin,f PSA,PSA,βHCG及HGH)的水平,分析其差异,并评估该方法的应用价值。结果在单项指标中,大肠癌患者血清CEA、CA199、CA242和CA125阳性率分别为48.20%、32.37%、28.06%和28.06%,均显著高于良性病变组(P<0.01)。采用多项指标判定标准的结果,联合检测既可以提高诊断敏感性,也可以获得较好的特异性。结论多种肿瘤标志物蛋白芯片联合检测对大肠癌诊断具有辅助价值,其中CEA、CA199、CA242和CA125的诊断价值较高。
Objective To evaluate the diagnostic values of combined detection of multiple tumor marker protein using protein chip in colorectal cancer. Methods The serum concentrations of 12 tumor markers (CA19-9, NSE, CEA, CA242, CA125, CA15-3, AFP, ferritin, f-PSA, PSA, β-HCG and HGH) in 139 patients with colorectal cancer and 63 patients with benign colorectal lesions was determined and analyzed by C-12 multi-tumor markers protein chip diagnosis system, and its diagnostic values were evaluated. Results In single tumor marker detection, the positive rate of CEA, CA19-9, CA242 and CA125 was 48.20%, 32.37%, 28.06% and 28.06% in the colorectal cancer group, respectively, which was significantly higher than in the control group. Combined measurement of the multiple markers had higher sensitivity and better specificity. Conclusions Combined measurement of multiple tumor markers by C-12 protein chip diagnosis system is helpful for the diagnosis of colorectal cancer, and the detection of CEA, CA19-9, CA242 and CA125 has better value in the diagnosis of colorectal cancer.
出处
《消化外科》
CSCD
2005年第4期268-270,共3页
Journal of Digestive Surgery
关键词
大肠癌
肿瘤标志物
蛋白芯片
诊断
colorectal cancer tumor marker protein chip diagnosis
