摘要
目的探讨分析乳腺癌组织中C-erbB-2、增殖细胞核抗原(PCNA)及雌、孕激素受体(ER、PR)的表达及其意义。方法采用免疫组化法检测269例乳腺癌组织中C-erbB-2、PCNA、ER、PR的表达情况。结果乳腺癌组织中C-erbB-2、PCNA、ER、PR的阳性表达率分别为69.52%、78.81%、51.67%和59.48%。C-erbB-2表达与乳腺癌患者腋淋巴结转移及肿瘤的浸润性相关(P<0.01);PCNA表达仅与腋淋巴结转移相关(P<0.01),而与肿瘤的浸润性无关(P>0.05);ER、PR表达呈正相关(r=0.522,P=0.000),C-erbB-2、PCNA表达呈正相关(r=0.182,P=0.003)。结论联合检测乳腺癌组织中C-erbB-2、PCNA、ER、PR的表达对于乳腺癌的治疗具有指导意义,也是判断预后的重要指标。
Objective To investigate the expression and clinical significance of C -erbB -2, PCNA, ER and PR in breast cancer. Methods Expression of C - erbB - 2, PCNA, ER and PR were detected by using immunohistochemical method in 269 breast cancer tissues. Results Positive rates of C - erbB - 2, PCNA, ER and PR were found to be 69.52%, 78.81%, 51.67% and 59. 48%, respectively. The expression of C -erbB -2 was correlated with lymph node metastasis and tumorous invasion （P 〈 0.05 ）. The expression of PCNA was only correlated with lymph node metastasis （P 〈 0.05 ）. The expression of C - erbB - 2, PCNA, ER and PR were positive correlated （P 〈 0.05 ）. Conclusions The expression of C - erbB - 2, PCNA, ER and PR has an instructive significance for predicting the prognosis of breast cancer patients.
出处
《宁夏医学杂志》
CAS
2009年第2期104-105,共2页
Ningxia Medical Journal
