摘要
目的:探讨加味四妙勇安汤对慢性脑供血不足患者血管内皮功能障碍和血栓前状态的干预效果。方法:90例慢性脑供血不足患者按就诊时间顺序分为A组(对照组)、B组(加味四妙勇安汤组)、C组(联合用药组)各30例,分别观察3组患者用药前和用药3个月后一氧化氮(NO)、血管内皮素-1(ET-1)、纤维蛋白原(FIB)、组织型纤溶酶原激活物抑制物(PAI-1)和组织型纤溶酶原激活物(t-PA)的变化及内皮依赖性血管舒张功能(EDD)、非内皮依赖性血管舒张功能(NEDD)的变化,并进行对比分析。结果:B组、C组经过治疗后,NO水平升高.ET-1水平和FIB减低,t-PA活性增强,PAI-1活性降低,EDD显著改善,两治疗组组间相比差异无统计学意义(P>0.05)。两治疗组治疗后分别与对照组相比差异具有统计学意义(P<0.05)。结论:服用加味四妙勇安汤能够有效改善慢性脑供血不足患者的血管内皮依赖性舒张功能及血栓前状态,可以作为脑血栓形成的一级预防治疗。
This is a study to understand the effects of Simiaoyongantang on the vascular endothelium function and Prethrombotic state in the Patients with chronic cerebral circulation insufficiency （CCCI）. In the study, 90 patients with CCCI were randomly divided into 3 groups： a control group, a Simiaoyongantang group, and a mixed treatment group, to observe the variation of NO, ET-1, FIB, PAI-1, t-PA, EDD, and NEDD in their body before and after the treatment. Results collected three months after the treatment show that both groups B and C had a significantly raised NO and t- PA level, and an improved EDD, though ET-1, FIB, and PAI-1 level became significantly reduced. There was no statistical difference between groups B and C. However, a comparison between the control group and groups B and C has revealed a statistical difference. It is concluded that Simiaoyongantang can improve the vascular endothelium function and Prethrombotic state of the patients with CCCI. It can be considered as a Primary Prevention treatment of cerebral thrombosis.
出处
《世界科学技术-中医药现代化》
2008年第6期41-44,共4页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
华北煤炭医学院院级资金资助项目(076281):四妙勇安汤在预防慢性脑供血不足患者发展为脑梗死中的作用,负责人:杜志刚
关键词
慢性脑供血不足
加味四妙勇安汤
血管内皮功能
血栓前状态
Chronic cerebral circulation insufficiency （CCCI）, Vascular endotheliurn function, Prethrombotic state, Simiaoyongantang
