摘要
针对慢性虚证病理改变具有内在性、其模型较难复制的现状，初步观察了病理生理对比性较强的两种证型——大鼠长期（２６周）脾虚造模和热证造模的多脏器组织病理。结果表明，长期脾虚造模的病理变化以慢性炎症及各脏器退行性病变为主，这是较短期的造模所不及的；长期热证造模的病理变化与脾虚组有类似趋势，但组织病理上有显著不同，各脏器损伤不严重，免疫功能受损也轻。由此说明，长期脾虚和热证造模的病理变化是在增龄引起的病理生理变化的基础上发生的，但各有其特点。
UMMARY:Considering the pathologic characteristics of chronic deficiency syndrome of which animal models were made difficultiy, the various organs pathological changes of long-term (26 weeks) spleen deficiency and heat syndrome mice models were tentatively observed. The results showed that the main pathologic changes of long-term spleen deficiency syndrome models were chronic inflammation and several organs retrograde affection, which were different from that of short-term models; the main pathologic changes of long-term heat syndrome models were similar to long-term spleen deficiency syndrome models, but the damages of organs and immunological function were less than the long-term spleen deficiency syndrome models. It was suggested that the main pathological changes of long-term spleen deficiency and heat syndrome models were caused by aging and had individual characteristics respectively.
出处
《成都中医药大学学报》
1997年第4期32-34,F003,共4页
Journal of Chengdu University of Traditional Chinese Medicine
基金
国家自然科学基金
关键词
脾虚证
热证
慢性证候
动物模型
中医
Spleen deficiency syndrome
Heat syndrome
Chronic syndrome
Animal model
Histopathological changes
