摘要
目的分析铜绿假单胞菌院内感染分布的概况、特征及耐药性，指导临床合理使用抗菌药物。方法利用湖南天地人微生物分析系统对海南医学院附属医院2005年1月～2007年12月临床分离的391株铜绿假单胞菌耐药情况进行分析，统计391株铜绿假单胞菌感染其分布情况。结果391株铜绿假单胞菌对各种抗生素的耐药率为：氨苄西林／舒巴坦92．8％、美洛西林81．1％、氯霉素83．0％、复方新诺明76．O％、头孢曲松84．9％、头孢噻肟84．4％、哌拉西林，他唑巴坦54．2％、头孢哌酮66．2％、庆大霉素69．6％、妥布霉素66．8％、阿米卡星64．7％、左氟沙星40．4％、氨曲南59．3％、环丙沙星45．0％、头孢他啶54．0％、头孢吡肟50．4％、美洛培南23．3％。结论铜绿假单胞菌院内感染情况严重，以ICU病区、呼吸内科病区和神经外科病区最为严重，美洛培南可作为治疗的首选，其次为左氟沙星、环丙沙星、头孢吡肟、头孢他啶。因此，应加强对铜绿假单胞菌耐药性的监测，以降低其耐药性控制多重耐药菌株的出现和院内感染扩散。
Objective To analyse the distribution and drug resistance of Pseudomonas aerugirtosa （P.aeruginosa） to antibiotics in hospital infection. Methods The drug resistance of 391 strains of P.aeruginosa isolated from affiliated hospital Hainan Medical College from Jan 2005 to Dec 2007 to antibiotics were analysed by using Hunan Heaven, Earth, microbial analysis system. Results The resistant rates of P.aeruginosa to ampicillin/sulbactam , mezlocilIin,chloromycetin, TMP-SMZ, ceftriaxone cefotaxim were the highest being 92.8%, 81.1%, 83.0%, 76.0%, 84.9%, 84.4%, respectrivelly. The resistance to other antibiotics varied between 69.6% - 50.4% and the lowest was to meropenem （23.3%）. Conclusion Hospital infection is high , especially in ICU, respiratory care wards wards and neurosurgery wards. Meropenem should be the first choice of antimicrobial agents for treating clinical infection with P. aeruginosa, then followed by levofloxacin, ciprofloxaein, cefepime and ceftazidime.
出处
《中国热带医学》
CAS
2008年第12期2227-2228,共2页
China Tropical Medicine
关键词
铜绿假单细胞菌
院内感染
耐药性
Pseudomonas aeruginosa, Hospital infection, Drug resistance
