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哌拉西林与加替沙星联合对铜绿假单胞菌的联合药敏研究

The study on the antibacterial activity of piperacillin combined with gatifloxacin against Pseudomonas aeruginosa
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摘要 评价哌拉西林与加替沙星联合用药,对30株临床分离的铜绿假单胞菌的体外联合抗菌效应.采用棋盘法设计,微量肉汤稀释法测定.测定不同浓度组合的抗菌药物对30株临床分离的铜绿假单胞菌的最低抑菌浓度,并计算FIC指数判定联合效应.FIC≤0.5为协同作用,0.5＜FIC≤1为相加作用,1＜FIC≤2为无关作用,FIC＞2为拮抗作用.哌拉西林与加替沙星联合应用后,其MIC50显著降低.FIC指数分布:FIC≤0.5占40%;0.5＜FIIC≤1占50%;1＜FIC≤2占10%;FIC＞2为0.结果表明加替沙星与哌拉西林联合用药后,对铜绿假单胞菌基本表现为协同作用和相加作用,并以协同作用为主,无关作用较少,无拮抗作用.
作者 任浩洋 周筱青 裴斐 王睿 柴栋 方翼
机构地区 解放军总医院药材处
出处 《中国药物应用与监测》 CAS 2003年第5期59-61,共3页 Chinese Journal of Drug Application and Monitoring
关键词 哌拉西林 加替沙星 铜绿假单胞菌 联合药敏
分类号 R9 [医药卫生—药学]
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参考文献7

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共引文献421

中国药物应用与监测
2003年 第5期

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