摘要
糖尿病肾病是糖尿病最为严重的并发症之一,严重危害人类的健康。研究表明,糖尿病肾病的发生和发展并不完全与血糖控制及病程成正比,其发病具有家庭聚集现象及种族差异;除环境因素外,遗传因素在其发生和发展过程中具有重要作用,如许多基因突变可以导致糖尿病肾病的高度易感性。随着糖尿病肾病相关基因的发现及其功能的阐明将为糖尿病肾病的早期诊断、基因治疗和个体化药物治疗提供了有效的手段。该文对已经发现的与糖尿病肾病发生发展相关的一些基因及其功能进行了综述。
Diabetic nephropathy is one of the most serious complications of diabetes mellitus and it seriously endangers people＇ s health. Some previous studies indicate that the occurrence and development of diabetic nephropathy is not positively associated with control of blood glucose and course of disease, Its development has family aggregation and ethnic differences. In addition to environmental factors, genetic factors play an important role in the process of occurrence and development of diabetic nephropathy, Many genetic mutations can lead to a high degree of susceptibility to diabetic nephropathy. Discovery of some related genes of diabetic nephropathy and elucidation of these genes function provide an effective means in the early diagnosis, gene therapy and individualized drug therapy of diabetic nephropathy. In this review the action and function of discovered related genes of diabetic nephropathy are summarized.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第11期1419-1422,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30572230)
湖南省“芙蓉学者计划”特聘教授资助项目(湘教通[2006]312号)
关键词
糖尿病
糖尿病肾病
基因多态性
diabetes mellitus
diabetic nephropathy
genetic polymorphism
