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糖尿病肾病患者血清透明质酸、Ⅳ型胶原、Ⅲ型前胶原测定的临床意义 被引量:4

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摘要 目的观察糖尿病肾病患者血清透明质酸(HA)、Ⅳ型胶原(CIV)、Ⅲ型前胶原(PCⅢ)检测值的变化,探讨其临床意义。方法选择50例2型糖尿病患者和30例健康成人。50例2型糖尿病患者分别按其空腹血糖水平和尿中白蛋白含量分成血糖控制不良组、血糖控制较好组,尿白蛋白正常组、尿白蛋白微量组、尿白蛋白大量组,检测其血清HA、CIV、PCⅢ含量。结果2型糖尿病患者血清HA、CIV、PCⅢ水平显著高于对照组(P<0.01,P<0.01,P<0.05),血糖控制不良组糖尿病患者血清三项指标分别显著高于血糖控制较好组(P<0.01,P<0.05,P<0.01);尿白蛋白大量组其三项指标高于尿白蛋白微量组,而尿白蛋白微量组三者水平高于尿白蛋白正常组(P<0.01)。结论2型糖尿病患者血清HA、CIV、PCⅢ水平较正常组显著升高,并与血糖水平的控制密切相关,反映了糖尿病肾病的进展。
出处 《海南医学》 CAS 2005年第3期135-136,共2页 Hainan Medical Journal
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共引文献35

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