摘要
目的探讨伴阻塞性睡眠呼吸暂停低通气综合征(OSAHS)肥胖儿童血清瘦素(LP)和脂联素(AP)水平及其相关性。方法选择经多导睡眠记录仪(PSG)确诊的41例OSAHS患儿,将其分为OSAHS肥胖组(21例)、OSAHS非肥胖组(20例);另选保健科门诊就诊的28例儿童分为单纯肥胖组(18例)和健康对照组(10例)。采用放射免疫法检测各组儿童血清LP和AP水平,并分析OSAHS肥胖患儿血清LP和AP水平与体质量指数(BMI)、呼吸睡眠紊乱指数(AHI)的相关性。结果单纯肥胖组、OSAHS非肥胖组、OSAHS肥胖组血清LP水平依次升高,且均高于健康对照组(Pa<0.05),血清AP水平则依次减低,且均显著低于健康对照组(Pa<0.05);OSAHS肥胖组血清LP水平分别与BMI、AHI呈显著正相关(r=0.59,0.79 Pa<0.01),血清AP水平与BMI、AHI及LP水平呈显著负相关(r=-0.59,-0.67,-0.76 Pa<0.01)。结论OSAHS肥胖患儿血清LP水平升高、AP水平减低与其体内存在LP抵抗和AP合成反馈调节机制障碍有关,LP、AP、肥胖与儿童OSAHS有独立的相关性。
Objective To explore the changes of the levels of serum leptin （LP）and adiponectin （AP） in obese children with obstructive sleep apnea - hypopnea syndrome （OSAHS） and their relationships. Methods Forty - one cases of obese children with OSAHS diagnosed by the polysomnogram （PSG） were divided into 2 groups：the OSAHS of obese group（21 cases） ,non - OSAHS of obese group（20 cases ）. Twenty -eight cases of out -patient children were divided into 2 groups：the simple obese group （18 cases） and healty control group（ 10 cases）. Levels of serum LP and AP were measured by radio - immunity assay. Correlations between the levels of LP/AP and body mass index （BMI） ,apnea hyponea index （AHI） were analyzed. Results Levels of serum LP in simple obese group, OSAHS of obese group and non - OSAHS of obesity group were increased, which were significantly higher than those in healthy control group （P. 〈 0.05 ）, the levels of serum AP were decreased and significantly were lower than that in healthy control group（ P 〈 0.05 ）. Levels of serum LP in the OSAHS of obese group was positively correlated with BMI, AHI（ r=0. 59,0.79 Pa 〈 0. 01 ）, while the serum AP were negatively correlated with BMI, AHI andLPlevel（r=-0.59,-0.67,-0.76 Pa〈0.01）.Conclusions Tbe increase of serum LP and the decrease of AP in the OSAHS children are correlated with the resistance of LP and the feedback obstacles of AP in synthetic mechanism, LP,AP and obesity and children OSAHS are independently correlated.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2008年第20期1592-1593,共2页
Journal of Applied Clinical Pediatrics
