摘要
目的探讨心率变异性对不同程度阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者心功能诊断与评估的临床价值。方法 119例OSAHS患者根据睡眠呼吸暂停低通气指数(apnea-hypopnea index,AHI)分为对照组、轻度组、中度组、重度组,完善所有患者颈围、体重指数信息,并进行多导睡眠图检查和心率变异性分析。结果OSAHS疾病程度与颈围、体重指数及AHI均呈正相关(r=0.763,0.615,0.825,P<0.05);与昼、夜24小时内每5分钟节段平均常RR间期标准差(standard deviation of all the 5-minaverage ofN-N interval,SDANN_昼、SDANN_夜)呈正相关(r=0.821,0.793,P<0.05);与昼、夜低频能(low frequency energy,LF_昼、LF_夜)以及昼高频能(high frequency energy,HF_昼)呈正相关(r=0.534,0.829,0.645,P<0.05);但与昼、夜全程RR间期差值的均方根(root mean square of successive N-N interval difference,rMSSD_昼、rMSSD_夜)、HF夜呈负相关(r=-0.652,-0.871,-0.738,P<0.05)。结论心率变异性分析能有效反映心脏自主神经张力的变化,结合颈围、AHI、体重指数,对OSAHS患者疾病程度分级与治疗具有指导意义。
Objective To investigate the clinical value of heart rate variability （HRV） in the diagnosis and evaluation of cardiac function in patients with different degrees of obstructive sleep apnea-hypopnea syndrome （OSAHS）. Method According to the index of apnea-hypopnea index （AHI）, 119 patients with OSAHS were divided into the control group, the mild group, the moderate group and the severe group. All patients were collected the information of neck circumference and the index of body mass index （BMI）, and completed the polysomnogram （PSG） examination and HRV analysis. Result Disease severity of OSAHS was positively correlated with neck circumference and indexes of BMI and AHI （r=0.763, 0.615, 0.825, P〈0.05）, and same to the indexes of day and night standard deviation of all the 5-minaverage of N-N interval （SDANNday, SDANNnight）（r=-0.821, 0.793, P〈0.05）, and same to the indexes of day and night low frequency energy （LFday, LFnight）, and night high frequency energy （HFnight） （r=0.534, 0.829, 0.645, P〈0.05）; but it was negatively correlated with the indexes of day and night root mean square of successive N-N interval difference （rMSSDday, rMSSDnight） and HFnight （r=-0.652, -0.871, -0.738, P〈0.05）. Conclusion HRV analysis can effectively reflect the changes of cardiac autonomic nervous tension, combined with the neck circumference, the indexes of BMI and AHI, which has a guiding significance in the classification of disease degree and treatment for patients with OSAHS.
出处
《中国医刊》
CAS
2016年第1期78-82,共5页
Chinese Journal of Medicine
