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常山碱和异常山碱的合成研究进展 被引量：5

Progress on Total Synthesis of Febrifugine and Isofebrifugine
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摘要 常山碱和异常山碱目前主要用于家禽抗球虫病,具有高抗疟性、无副作用的优点,属喹唑啉酮类化合物.最新研究发现,此类化合物可用于膀胱、前列腺、乳腺、皮肤、肺癌等恶性肿瘤的治疗,市场前景广阔.综述了常山碱和异常山碱的的合成发展,探讨分析了多种合成路线. Febrifugine and isofebrifugine, which belong to quinazolinones, derived from Chinese hydrangea called ＂ChangShan＂ are having highly effective anticoccidials at extremely low dosages yet with little side effect. The present discovery shows that certain of these quinazolinones are effective for treating human malignancies including vesica, prostate, mammary,lung cancers and cutaneum carcinoma. The article reviews the progress on the total synthesis of the febrifugine and isofebrifugine.
作者 张越 杜会茹 王永国 牛玉环
机构地区 河北科技大学化学与制药工程学院
出处 《河北师范大学学报（自然科学版）》 CAS 北大核心 2008年第4期510-516,共7页 Journal of Hebei Normal University：Natural Science
基金 河北省自然科学基金(203361)
关键词 常山碱 异常山碱 抗疟活性 合成 综述 febrifugine isofebrifugine antimalarial activity synthesis review
分类号 O626 [理学—有机化学]
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参考文献34

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同被引文献73

  • 1周丽霞.喹唑啉酮类化合物的生物活性研究进展[J].生物灾害科学,2012,35(2):142-148. 被引量：2
  • 2金光明,丁希强.直杀球虫与强力灭球王对鸡柔嫩艾美耳球虫的疗效观察[J].中国畜牧兽医,2004,31(12):42-44. 被引量：10
  • 3安健,汪明,王黎霞,盛守强.球虫抗药性分子生物学检测技术的建立[J].中国兽医学报,2007,27(3):340-342. 被引量：11
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  • 5Jiang S, Zeng Q, Gettayacamin M, et al. Antimalarial activities and therapeutic properties of febrifugine ana- logs[J]. Antimicrob Agents Chemother, 2005,49 (3) : 1169-1176.
  • 6Nagler A,Ohana M, Shiholet O,et al. Suppression of hepatocellular carcinoma growth in mice by the alka- loid coccidiostat halofuginone[J]. European J Cancer, 2004,40 : 1397-1403.
  • 7Zhu S, Zhang Q, Gudise C, et al. Synthesis and biologi cal evaluation of febrifugine analogues as potential an timalarial agents[J]. Bioorganie Med Chem, 2009,17 4496-4502.
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  • 10Ye W, You .l H, Li X, et al. Design, synthesis and anti- coccidial activity of a series of 3-(2-(2-methoxyphe- nyl)-2-oxoethyl) quinazolinone derivatives[J]. Pesti- cide Biochem Physiol, 2010,97 : 194-198.

引证文献5

二级引证文献15

河北师范大学学报（自然科学版）
2008年 第4期

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