摘要
为评价常山总碱的安全性和今后系统研究其药理作用以及为临床安全用药提供试验依据,在小鼠急性毒性试验的基础上,进行亚急性毒性试验。80只大鼠随机分成常山总碱高、中、低剂量组和空白对照组,药物组按照大鼠体质量6.50,3.25,1.63g/kg的剂量灌胃给药,连续给药14d,所有大鼠于给药后分2次(7,14d)扑杀。结果表明,常山总碱低、中剂量组大鼠的体质量、脏器系数、血液学指标、血液生化指标、组织病理学变化等各项指标与对照组比较均无显著性差异(P>0.05);高剂量组对上述部分指标有一定影响,需要进一步研究。本试验结果提示,常山总碱的毒性很低,临床用药较为安全。
To evaluate the safety of total dichroa alkaloid（TDA） and probe its pharmacological effect in future, suba- cute toxicity test was carried out based on mouce acute toxicity. 80 rats were randomly divided into the experimental group（EG） and the control group（CG）, in the fomer which were taken TDA at doses of 6.50,3. 25,1.63 g/kg, named high dose group（HG）, medium dose group（MG） ,low dose group（LG） respectively. The EG were continuous- ly performed by intragastric administration for 14 d and all rats were killed at 7 d and 14 d. The results showed that related indexes of the LG and MG had no significant difference contrasted to the CG（P^0.05）,such as the weight, organ coefficient, haematological index, blood biochemical index,pathological changes and so on. However, part inde- xes of HG had certain changes and needed further study. Our research suggested that the toxicity of TDA was very low and could be used safely in clinic.
出处
《中国兽医学报》
CAS
CSCD
北大核心
2012年第8期1207-1211,共5页
Chinese Journal of Veterinary Science
基金
中央级公益性科研院所专项资金资助项目(1610322011004)
关键词
常山总碱
亚急性毒性试验
抗球虫
大鼠
total dichroa alkaloid （TDA）
subacute toxicity test ~ anticoccidial
rat
