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Pirh2mRNA在原发性乳腺癌中的表达意义 被引量：6

The significance of Pirh2 mRNA expression in primary breast cancer
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摘要 目的探讨Pirh2 mRNA在乳腺肿瘤组织中的表达及其与乳腺癌发生发展的关系。方法回顾性分析湘雅医院乳腺科近10年间收治的乳腺肿瘤患者的临床资料,其中包括I,II期乳腺癌87例,III,IV期乳腺癌27例Pirh2 mRNA的表达,并以纤维瘤组织10例和正常乳腺组织6例作为对照。结果Pirh2 mRNA在乳腺癌组织中阳性表达率为43.9%(50/114),10例纤维瘤组织1例阳性,6例正常乳腺组织无表达。乳腺癌与纤维瘤和正常乳腺组织间的Pirh2 mRNA表达均有差异显著性(P=0.004)。I,II期乳腺癌和III,IV期乳腺癌中阳性率分别为37.9%(33/87)和63.0%(17/27),差异有显著性(P=0.022)。114例乳腺癌中5年内远处转移者60例,其Pirh2 mRNA阳性率为63.3%(38/60);无瘤生存≥5年者54例,其Pirh2 mRNA阳性率为22.2%(12/54),两者有差异有显著性(P=0.000)。结论Pirh2 mRNA在乳腺癌组织中呈较高表达,而在乳腺纤维瘤和正常组织中几乎不表达;在III,IV期阳性表达明显高于I,II期乳腺癌。Pirh2 mRNA可能与乳腺癌的发生发展有密切关系。 Objective To investigate the expression of Pirh2 mRNA in breast cancer tissue and its correlation to genesis and development of breast cancer. Methods A retrospectively analysis of pirh 2 mRNA expression in 87 cases of stage Ⅰ and Ⅱ breast cancer, 27 cases of stage Ⅲ and Ⅳ breast cancer was made, and 10 cases of fibroma tissue and 6 cases of normal lacteal gland tissue as control, all of which were from Department of Breast Surgery, XiangYa Hospital in recent 10 years. The in situ hybridization was used to detect the expression of Pirh2 mRNA. Results The positive rate of Pirh2 mRNA in breast cancer tissue was 43.9 % （50/114 ） , 1 positive in 10 cases of fibroid tumor, and no expression in normal lacteal gland tissue. The expression of Pirh2 mRNA in breast cancer was significant higher than that in fibroid tumor and normal lacteal gland （ P = 0. 004 ）. The positive rate of the stage I or II breast cancer group and was 37.9% （33/87） and of stage III or IV was 63% （17/27） respectively, with a significant difference （P =0.022 ）. In the 60 cases with metastasis occurred in less than 5 years the positive rate of Pirh2 mRNA was 63.3% （38/60） , and the positive rate of the 54 non-tumor survivors was 22.2% （12/54） （ P = 0. 000 ）. Condusions Pirh2 mRNA is more highly expressed in breast cancer, while there is almost zero expression in lacteal gland fibroid and normal tissue. The positive expression in stage Ⅲ or Ⅳ is significantly higher than breast cancer of stage Ⅰ or Ⅱ. Pirh2 mRNA is probably closely correlated to the genesis and development of breast cancer.
作者 张超杰 唐利立 欧阳慧英 任力锋 邬玉辉 罗庚求
机构地区 湖南省人民医院乳甲外科 中南大学湘雅医院乳腺科 中南大学生物医学工程研究院 中南大学湘雅医学院病理学系
出处 《中国普通外科杂志》 CAS CSCD 2008年第5期444-448,共5页 China Journal of General Surgery
基金 湖南省卫生厅课题资助项目(B2005-021)
关键词 乳腺肿瘤/病理学 PIRH2 MRNA 原位杂交 Breast Neoplasms/pathol Pirh2 mRNA In Situ Hybridization
分类号 R737.9 [医药卫生—肿瘤]
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参考文献14

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二级参考文献11

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共引文献3

同被引文献84

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中国普通外科杂志
2008年 第5期

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