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喉鳞癌原发灶和切缘BAG-1蛋白表达及其与术后复发的关系 被引量:2

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摘要 目的:探讨喉鳞癌原发灶和切缘BAG-1蛋白表达及其与术后复发的关系。方法:采用免疫组化方法检测31例资料齐全的复发性喉癌患者的原发灶、复发灶及切缘BAG-1蛋白表达情况,并以20例喉癌术后随访满5年以上至今未复发者作为对照组进行比较分析。结果:31例复发性喉癌的原发灶和复发灶的BAG-1蛋白阳性表达分别为74.2%、67.7%,两者差异没有显著性;20例对照组喉癌原发灶的BAG-1蛋白阳性表达为75.0%,与复发组喉癌原发灶的BAG-1蛋白阳性表达率相比,两者差异也没有显著性;31例复发组喉癌手术切缘及20例对照组喉癌手术切缘BAG-1蛋白阳性表达分别为41.9%、15.0%,两者之间差异有显著性。结论:BAG-1蛋白在常规阴性病理切缘的表达与喉癌术后复发有关,为今后筛选预测术后肿瘤局部复发的高危病例提供了依据。
出处 《实用医学杂志》 CAS 2008年第9期1543-1544,共2页 The Journal of Practical Medicine
基金 温州市科技计划项目(编号:Y20060256)
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