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胶原性关节炎大鼠滑膜组织β-arrestin 1和β-arrestin 2的表达 被引量：2

The expression of beta-arrestin 1 and beta-arrestin 2 in the synovium of collagen-induced arthritis rats
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摘要 目的探讨胶原性关节炎(C IA)大鼠滑膜组织β-ar-restin 1和β-arrestin 2的表达及其意义。方法采用W estern blot法检测大鼠在第0、14、21、28、35天不同时间点滑膜组织β-arrestin 1和β-arrestin 2的表达。结果第0、14、21、28、35天β-arrestin 1表达差异无显著性;与0 d未致炎组相比,β-arrestin 2表达从14 d开始上调,在28 d达最大值,差异有显著性(P<0.01)。结论C IA大鼠滑膜组织β-arres-tin 2表达上调。 To study the beta-arrestins expression in the synovium of collagen-induced arthritis （CIA） rats. Methods We investigated beta-arrestins expression in synovial tissue in CIA rats on different days by Western blot and semi-quantification of gray scale. Results There were no significant differences in the expression of beta-arrestin 1 on different days after immunization. However, we found that the expression of beta-arrestin 2 of synovial tissue in CIA rats increased significantly on day 14,21,28,35 compared with that on day 0 after immunization. Conclusion The expression of beta-arrestin 2 of synovial tissue in CIA rats increases apparently.
作者 吴华勋 陈镜宇 严尚学 张玲玲 汪庆童 魏伟
机构地区 安徽医科大学临床药理研究所
出处 《安徽医科大学学报》 CAS 北大核心 2008年第2期163-165,共3页 Acta Universitatis Medicinalis Anhui
基金 国家自然科学基金资助项目(30572356) 安徽省自然科学基金资助项目(050430903) 安徽省科技攻关计划项目(06013133B) 高等学校博士学科点专项科研基金(20060366003) 安徽省高等学校青年教师基金(2005jq1090) 安徽高校首批科技创新团队基金 安徽省研究实验基地优秀中青年科研带头人基金 安徽医科大学青年教师基金
关键词 关节炎 实验性 滑膜 arthritis, experimental synovial membrane
分类号 R684.3 [医药卫生—骨科学] R341 [医药卫生—基础医学]
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参考文献9

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共引文献29

同被引文献18

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安徽医科大学学报
2008年 第2期

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