摘要
为了给临床提供特异有效的治疗婴幼儿轮状病毒感染的生物制剂，以ＳＡ１１轮状病毒免疫受孕乳牛，制备抗轮状病毒免疫牛初乳，从临床治疗角度，对８０例婴幼儿急性轮状病毒感染性腹泻，４３例应用抗轮状病毒牛初乳治疗，３７例应用思密达治疗，对两组进行了疗效对比观察。结果表明：抗轮状病毒免疫牛初乳治疗组的总有效率，显效率和７２小时粪便病毒转阴率分别达９１％，７９％和８９％；而思密达治疗组的疗效及７２小时大便病毒转阴率则相应为４１％，２４％和３９％，差异均有非常显著意义。为临床治疗婴幼儿轮状病毒感染性腹泻提供了安全有效。
The purpose of this study was to evaluate efficacy and safety of immune cow′s colostrum in treatment of infantile rotavirus gastroenteritis. Pregnant cows were immunized with rotavirus SA11 strain, cow′s colostrum containing antibody to human rotavirus was collected. Eighty infants with rotavirus gastroenteritis confirmed by ELISA method were divided into two groups randomly. There were forty three cases in the group treated by colostrum, and thirty seven cases in control group treated with Smecta. The patients were given ora1 administration of colostrum or smecta, three times a day for three days, respectively. The therapeutic effect was evaluated based on durations of diarrhea and persistence of rolavirus antigen in stool. In the colostrum group, the diarrhea stopped within 48 hours in 34 of 43 cases, and within 72 hours in 5 of 43 cases. Whereas, in the control group in 9 out of 37 cases the diarrhea disappeared within 48 hours and in 6 out of 37 the diarrhea stopped within 72 hours. The therapeutic effect of colostrum was significantly superiors to that of the smecta ( P <0.01). Rotavirus antigen became undetectable within 72 hours in 89% of the cases (25/28) in the colostum group and in 39% (9/23) in the control group ( P <0.01). These results demonstrated that oral auministration of rotavirus immune colostrum might be an effective and safe treatment of diarrhea caused by human rotavirus infection.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1997年第7期353-355,共3页
Chinese Journal of Pediatrics
