摘要
[目的]观察胆胃散袋泡剂的抗炎镇痛作用。[方法]用小鼠醋酸扭体实验观察镇痛作用,以二甲苯致小鼠耳肿胀实验观察抗炎作用。研究胆胃散袋泡剂低(1g/kg)、中(2g/kg)、高(3g/kg)剂量对小鼠扭体次数和耳肿胀度的影响。[结果]不同剂量的胆胃散能显著减少小鼠扭体次数、降低小鼠耳肿胀度,其作用强度与剂量呈一定的依赖关系;与阿司匹林比较,胆胃散袋泡剂各组对醋酸致小鼠扭体反应的镇痛效果弱于阿司匹林,而对二甲苯致小鼠耳肿胀度,高、中剂量的胆胃散袋泡剂的作用均强于阿司匹林。[结论]胆胃散袋泡剂有一定的抗炎镇痛作用,且其抗炎效果优于阿司匹林。
[Objective]To observe the activity of anti-inflammatory and analgesia of Danweisan.[Methods]The analgesia action of Danweisan was determined with twisting method, and the anti-inflammatory effect of Danweisan was evaluated with xylene induced ear tumefaction. The effects of the small, medium, large dosages of Danweisan group（2, 3, 4g/kg） on twisting and ear tumefaction in mouse were assessed. [Results] Compared with the normal group, it was shown to exert dramatic inhibitory effect with concentration-dependence on mouse twisting and ear tumefaction in the Danweisan group. [Conclusion] Danwesan has a remarkable analgesia activity and a better anti-inflammatory action than asprine.
出处
《浙江中医药大学学报》
CAS
2007年第4期420-421,共2页
Journal of Zhejiang Chinese Medical University
基金
浙江省医药卫生资助项目(No:20032C041)~~
关键词
胆胃散
抗炎
镇痛
小鼠
Danweisan
antl-inflammatory
analgesia
mouse
