摘要
以对叔丁基苯甲酸和甲醇为原料,甲基磺酸为催化剂合成对叔丁基苯甲酸甲酯,考察两种不同生产工艺A、B。工艺A采用一步法,当酸醇摩尔比1∶7,催化剂10%(占酸的摩尔份数),回流反应8h时,产率为85.8%。在上述条件下,工艺B将反应分两个阶段进行,第一阶段酸醇摩尔比1∶3.5,回流反应3h后蒸除水和甲醇;再加入与第一阶段同样量的甲醇,继续回流反应5h,产率高达95.3%。产品经红外和折光率进行表征。
p-tert-Butyl benzoic acid methyl ester was synthesized from p-tert-butyl benzoic acid and methanol using methanesul fonic acid as catalyst by two different production processes A and B. Process A used the one-step method, the yield 85.8% was obtained when the molar ratio of acid to alcohol is 1 ： 7, 10% catalyst （molar percent of acid）, and refluxed for 8 h. Under the same condition, the reaction was performed using process B, which was separated for two stages. In the first stage, the molar ratio of acid to methanol is 1 ： 3.5, methanol and the produced water were separated by distillation after refluxed for 3 h. Then the same amount of methanol as the first stage was added, the reaction refluxed for further 5 h, the yield of product was up to 95.3 %. The product was characterized by 1R and index of refraction.
出处
《香料香精化妆品》
CAS
2007年第5期11-13,共3页
Flavour Fragrance Cosmetics
关键词
对叔丁基苯甲酸甲酯
甲基磺酸
催化
酯化
p-tert-butyl benzoic acid rnethyl ester methanesulfonic acid catalysis esterification
