摘要
目的研究瑞芬太尼在全麻老年患者和成年患者中的药代动力学特征,并进行比较。方法8名老年组和8名成年组外科手术患者静脉给予瑞芬太尼5μg.kg-1,不同时间取血并处理血样,用HPLC/MS/MS方法测定全血中瑞芬太尼浓度;用3P97程序进行药代动力学数据处理,并比较2组的异同。结果静脉注射瑞芬太尼的血药浓度-时间曲线符合二房室模型,老年组和成年组主要的药代动力学参数分别为:t1/2β=(22.32±4.13),(21.28±11.52)min;CL=(2.68±1.12),(2.19±0.35)L.min-1;AUC=(142.69±54.93),(189.83±37.34)ng.min.mL-1。结论老年组和成年组的药代动力学参数几乎没有显著性差异,老年患者临床麻醉给药时无需调整给药方案。
Objective To study the pharmacokinetics of remifentanil in Chinese elder and adult patients, and to compare the pharmacokinetic results in the different patients in order to provid the theoretical evidence of clinical use of remifentanil. Methods After a single 5μg · kg^- 1 dose of remifentanil was given to 8 surgery elder patients and 8 surgery adult patients by iv administration route. The blood concentrations of remffentanil were measured by HPLC - MS/MS. The pharmacokinetic parameters of remifentanil were estimated by 3P97 software. Results The blood concentration - time profiles conformed to two compartment model after iv administration. The main pharmacokinetic parameters of remifentanil in elder and adult group were as follows ： t（1/2β） = （ 22. 32 ± 4. 13 ） min and （21.28 ± 11.52） min, respectively; CL = （2.68 ± 1.12） L ·min^-1 and （2.19 ± 0.35 ） L·min^- 1, respectively; AUC = （ 142.69 ± 54.93 ） ng ·min · mL^-1 and （189.83 ± 37.34）ng ·min·mL^-1, respectively. Conclusion There was nearly no significant difference in pharmacokinetics of elder and adult groups and no necessary to change the dosage schedule when gave remifentanil to elder patients in clinical practice.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2007年第5期362-364,共3页
The Chinese Journal of Clinical Pharmacology
基金
国家高技术研究发展863计划(No2003AA2Z3413)
