摘要
目的观察中药健脾渗湿汤对脾虚湿盛泄泻的患者肠道微生态及舌象变化的影响。方法选取脾虚湿盛泄泻的患者90例及正常健康人30例为研究对象,90例患者随机分为健脾渗湿汤治疗组30例,双歧三联活菌制剂贝飞达治疗组30例,氟哌酸治疗组30例,30例正常健康人作为对照组;观察治疗前后的舌象等临床表现,测定粪便中4种肠道常驻菌及舌部菌群的变化情况。结果健脾渗湿汤组和贝飞达组总有效率明显高于氟哌酸组。90例脾虚湿盛泄泻的患者粪便中双歧杆菌比健康人明显减少(P<0.05),并且其舌部(腻苔)的菌群构成与健康人(薄白苔)差异有显著性。治疗后健脾渗湿汤组和贝飞达组粪便中双歧杆菌增加明显,白腻苔及舌部菌群改善明显,说明健脾渗湿汤和贝飞达均具有调整肠道菌群及舌部菌群平衡的作用。结论(1)健脾渗湿汤具有调整肠道菌群及舌部菌群失调的作用,治疗脾虚湿盛泄泻疗效显著。(2)健脾渗湿汤是一理想的微生态调节剂,可起到益生元的作用,与益生菌合用可达到合生元的效果;与抗生素合用,可起到边抗边调的作用,应用前景广阔。
Objective To observe the effect of Jianpishenshitang on the intestine microecology and change of tongue phase of patient. Methods 90 spleen-deficiency patients were devided into three groups randomly,30 as group Jianpishenshitang ,30 as group Beifeida ,30 as group norfloxacin. 30 normal persons as contrastive group. To observe the clinical change after treatment and to examine the bacteria change of excrement and tongue coating. Results Jianpishenshitang and Beifeida were more effective than norfloxacin to the patients. The quantity of Bifidobacterium in 90 spleen-deficiency patients＇ excrement reduced obviously. The structure of tongue coating bacteria was diversed to the normal person. After treatment, quantity of Bifidobacterium in excrement of group Jianpishenshitang and group Beifeida was increased obviously. Conclusions （ 1 ） Jianpishengshitang adjusts the microdysbiosls of intestine and tongue coating, which is valid to spleen-deficiency patients. （2） Jianpishengshitang is a ideal microecology modulator.
出处
《中国微生态学杂志》
CAS
CSCD
2007年第5期439-441,共3页
Chinese Journal of Microecology
关键词
脾虚泄泻
健脾渗湿汤
肠道微生态
舌诊
Spleen-deficiency
Jianpishenshitang
Intestine microecology
Tongue-diagnose
Diarrhea
