摘要
目的：探讨病人的年龄、双侧卵巢基础状态及血清基础雌二醇（Ｅ２）水平与促超排卵后卵巢反应之间的关系。方法：对基础血清促卵泡激素（ＦＳＨ）＜２０ＩＵ／Ｌ、月经周期规律的女性不孕症病人１０２例、１０２个体外受精－胚胎移植周期，给予相同的促超排卵方案后，根据直径＞１０ｍｍ的卵泡数目将卵巢反应分为３种类型：低反应型（卵泡数＜３个）、中反应型（卵泡数３～１４个）和高反应型（卵泡数＞１４个）。结果：（１）年龄大于３５岁者卵巢低反应型的发生率增高，而小于３０岁者有发生高反应型的趋势。（２）卵巢基础状态的卵泡数目与促超排卵后卵泡发育数目呈正相关（Ｐ＜０．００１），当基础状态的双侧卵泡数多于２０时，极有可能发生卵巢高反应。（３）基础状态最大卵泡直径对卵巢反应类型有显著影响，当其直径大于４ｍｍ时，卵巢低反应型的发生率明显增加。（４）各反应类型之间基础血清Ｅ２水平无显著差异（Ｐ＞０．０５）。结论：年龄和双侧卵巢的基础状态，是预测促超排卵后的卵巢反应的重要因素。
Objective: To study the relationship between patient age, cycle day 3 basal ovarian status, serum estradiol (E 2) level and the ovarian response in an in vitro fertilization and embryo transfer (IVF ET) program. Method: 102 cases and 102 cycles of IVF ET patients with regular menstrual period and normal cycle day 3 basal follicular stimulating hormone (FSH<20 IU/L) level were studied. The same superovulation regimen was empolyed. The ovarian response was classified as low when follicle number (diameter>10mm) was fewer than 3 on the day of hCG injection, moderate when the number was 3～14, and high when follicle number exceeded 14. Results: (1) Patients older than 35 years tended to be low responders; women younger than 30 years usually responded well with production of more than 15 follicles. (2) The number of cycle day 3 follicles was positively correlated with the number after stimulation with gonadotropin. When total basal follicle number in both ovary exceeded 20, ovarian hyperstimulation syndrome should be watched out. (3) On cycle day 3 the diameter of the largest follicle was negatively correlated with the ovarian response. In low responders the diameter of the largest follicle was usually larger than 4mm. (4) Despite of the different size and number of the cycle day 3 follicles the serum E 2 level was quite similar. Conclusion: Age and basal ovarian status including the number and size of the antral follicles are valuable factors to be considered in the prediction of ovarian response to the same gonadotrophic stimulation protocol.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1997年第1期27-30,共4页
Chinese Journal of Obstetrics and Gynecology
关键词
卵巢
雌二醇
排卵诱导
Ovary Estradiol Ovulation induction
