摘要
目的探讨草酸钙尿结石形成的机制。方法应用红外光谱仪对66块尿结石标本进行检测,分析16例一水草酸钙(COM)与10例二水草酸钙(COD)结石患者的24h尿液生化指标,其检测结果利用SPSS软件进行t检验。结果87.5%的COM结石患者和90%的COD结石患者24h尿量减少;24h尿液生化检测,COM结石患者尿钙为(4.94±2.11)mmol/24h,而COD结石患者尿钙为(9.43±3.78)mmol/24h(P<0.01),COD结石患者尿磷为(28.38±10.21)mmol/24h,而COM结石患者尿磷为(20.50±8.76)mmol/24h(P<0.05);大部分COM结石患者尿钙、尿草酸、pH正常,尿枸橼酸则低于正常水平。结论COD结石患者尿钙、尿磷高于COM结石患者,表明二水草酸钙的形成与高钙尿及磷酸盐异质成核有关,而COM结石患者尿枸橼酸低于正常水平,可能与尿中抑制物缺乏有关。
[Objective] To study the mechanism of calcium oxalate urine stone formation. [Methods] 60 urinary stones were examined by infrared spectrophotometry. In 60 cases, 16 patients with calcium oxalate monohydrate （COM） and 10 patients with calcium oxalate dehydrate （COD） were selected for the study of some urinary parameters. The statistic study was carried out with SPSS t-test. [Results] The urinary excretions of 87.5% COM and 90% COD group of patients were reduced. Both calcium and phosphate varied obviously between the two groups of patients. In the COM group,the urinary calcium was （4.94±2.11） mmol/24 h whereas in COD group it was （9.43±3.78） mmol/24 h （P 〈0.01）. The urinary phosphate was （28.38±10.21） mmol/24 h in COD group whereas it was （20.50±8.76） mmol/ 24 h in the COM group （P 〈0.05）. Most of the COD group, urinary calcium, urinary oxalate, pH was in the normal, whereas urinary sodium citrate was lower than the normal. [Conclusion] Urinary excretions of both calcium and phosphate were higher in the COD group. It was postulated that the formation of COD might be related to hypercalcium or to phosphate heterogeneous nucleation whereas the formation of COM might be related to lackage of inhibitors.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第11期1359-1360,1364,共3页
China Journal of Modern Medicine
基金
湖南省郴州市科技局科研立项支助项目(No.05CK56-2)
湘南学院2006年重点立项科研课题(No.062007号)
关键词
尿结石
草酸钙
成因
urinary stone
calcium oxalate
formation
