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乳腺癌的药物预防 被引量：2

Chemoprevention of breast cancer
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摘要 药物通过直接或间接与雌激素作用起到预防乳腺癌之作用，主要预防药物包括三苯氧胺、雷洛昔芬、芳香化酶抑制剂和环氧合酶-2抑制剂等。常用乳腺癌风险预测模型为Gail模型和Claus模型，多组大宗临床试验正在进行以寻找预防乳腺癌的新手段。 Drugs can prevent breast cancer by directly and indirectly affecting estrogen. Prophylactic agents include tamoxifen, raloxifene,aromatase inhibitor, COX-2 and so on. Gail and Claus model are most used models for prediction of absolute risk of breast cancer. Many large clinical trials are ongoing in order to find new methods for preventing breast cancer.
作者 周亮（综述） 黄焰（审校）
机构地区 军事医学科学院附属
出处 《国际肿瘤学杂志》 CAS 2007年第4期267-269,共3页 Journal of International Oncology
关键词 乳腺肿瘤 化学预防 临床试验 Breast neoplasms Chemoprevention Clinical trials
分类号 R737.9 [医药卫生—肿瘤]
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参考文献14

  • 1Fisher B, Costantino JP, Wickerham DL, et al. Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study. J Natl Cancer Inst, 2005,97(22):1652-1662.
  • 2Cauley JA , Norton L, Lippman ME , et al. Continued breast cancer risks reduction in postmenopausal women treatment with raloxifene :4-year results from the MORE trial. Multiple outcome of raloxifene evaluation. Breast Cancer Res Treat,2001,65 (2) :125-134.
  • 3Martino S, Cauley JA, Barrett-Connor E, et al. Continuing outcomes relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifene. J Natl Cancer Inst,2004, 96(23) :1751-1761.
  • 4Land SR, Wickerham DL, Costantino JP. Patient-reported symptoms and quality of life during treatment with tamoxifen or raloxifene for breast cancer prevention: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA, 2006,295(23) :2742-2751.
  • 5Barrett-Connor E, Mosca L, Collins P, et al. Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women. N Engl J Med, 2006,355(2) :125-137.
  • 6Breast International Group (BIG) 1 - 98 Collaborative Group ; Thurlimann B, Keshaviah A, et al. A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. N Engl J Med, 2005,353(26):2747-2757.
  • 7Goss PE , Ingle JN ,Martino S ,et al. A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for earlystage breast cancer. N Engl J Med, 2003, 349 (19) :1793-1802.
  • 8Coombes RC ,Hall E ,Gibson LJ, et al. A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. N Engl J Med, 2004, 350 ( 11 ) :1081-1092.
  • 9Howell A, Cuzick J, Baum M, et al. Results of the ATAC ( Arimidex,Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet, 2005,365 (9453) :60-62.
  • 10Maurice A, Howell A, Evans DG, et al. Predicting compliance in a breast cancer prevention trial. Breast J, 2006,12 (5) :446-450.

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国际肿瘤学杂志
2007年 第4期

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