摘要
目的：采用不同疗程盐酸二甲胺四环素（派丽奥）辅助治疗慢性牙周炎并与牙周基础治疗相比较，旨在探讨用其治疗后不同阶段的疗效和最佳疗程。方法：用随机、单盲、自身对照的方法，以基础治疗为对照。将90名病人分成A、B、C3组，每组30人60个牙，每组中又分为实验组和对照组，各30个牙。A组为1个疗程组，B组为2个疗程组，C组为3个疗程组。观察基线、用药后1周、3个月、6个月的临床变化，A组延长观察至用药后9～12个月。记录治疗前后牙周探诊深度（PD）、附着丧失（AL）、菌斑指数（PLI）、龈沟出血指数（SBI）的改变并进行统计分析。结果：实验组与对照组比较：治疗后3组PD、AL各时段均有显著性差异（P〈0．01，P〈0、05），SBI、PLI在用药后1周、3个月均有显著性差异（P〈0.01），其余时间段均无显著性差异（P〉0．05），但除外A组PLI在用药6个月仍有显著性差异（P〈0．05）。3组疗效经Ridit分析，C组的实验组疗效最好。结论：牙周炎以机械洁治、刮治为基础，派丽奥局部辅助用药能提高疗效，并能稳定长期疗效，其中C组的实验组疗效最好。
AIM：To compare the clinical effect of subgingivally administration of minocycline in different course of treatment of chronic periodontitis with the basic treatment . The curative effect on the different stage and the best course of treatment were studied. METHODS ： Ninety patients of periodontitis were divided into 3 groups by randomized, double - blind, and single - control method. Every group had thirty - ones with sixty - tooth divided to the experimental and control group. Group A Periocline was administered for one treatment course, Group B for two courses, while Group C for three courses. The time interval of each course was three months. The clinic indexes changes were evaluated at baseline, week 1, month 3 and month 6, while Group A still contained month 9 and month 12. For three groups, standard clinical indices including probing depth （ PD ）, attachment loss （AL） , plaque index （ PLI ）, sulcus bleeding index （SBI） were recorded and analyzed. RESULTS： At the baseline, there was no significant difference in the indexes among the three groups. （ P 〉 0.05 ）. Both the PD and the AL had significant difference in each time. （P 〈 0.01 及 P 〈 0.05 ）. At week 1 ,month 3 after the treatment, the SBI and the PLI in the three groups had significant difference. （P 〈 0.01 ） It was no difference on the other time. （ P 〉 0.05 ） , but the PLI in group A had significant difference at month 6 （ P 〈 0.01 ）. The curative effect in the three groups was analyzed by Ridit test for each treatment. Which was best in the experimental group C. CONCLUSION： Administration of the local drug delivery system of periocline ointment as the auxiliary treatment of severe chronic periodontitis could get good clinical results The periocllne can stabilize long - time curative effect definitely. While the experimental group C was the best.
出处
《牙体牙髓牙周病学杂志》
CAS
2007年第2期98-102,共5页
Chinese Journal of Conservative Dentistry
基金
2003年广西卫生厅医疗临床科研课题(Z2003087)
