摘要
[目的]了解翼状胬肉中细胞周期蛋白依赖性激酶抑制剂P21的表达,探求其在翼状胬肉发病机制中的作用。[方法]收集切除的翼状胬肉及正常结膜组织标本,采用免疫组化方法进行细胞周期蛋白依赖性激酶抑制剂P21蛋白检测。[结果]翼状胬肉中P21表达为(5.03±0.34)%,而正常结膜组织中P21表达为(75.21±0.72)%,两组差异有统计学意义(P﹤0.01)。[结论]细胞周期蛋白依赖性激酶抑制剂P21在翼状胬肉中的低表达与失活可能使得翼状胬肉细胞周期紊乱,使其增殖失控。
[Objective] To study the expression of cyclin-dependent kinase inhibitor P21 in pterygium. [Methods] The pterygium and normal conjunctiva tissues were detected for cell circle related kinase inhibitor P21 with immunohistochemistry. [Results] The expression rates of P21 in conjunctiva and pterygium was （75.21±0.72） % and （5.03±0.34） %. There was significant difference between them （P 〈 0.01） . [Conclusion] The lower expression and inactivation of cell circle related kinase inhibitor in pteryginm may induce proliferation.
出处
《现代预防医学》
CAS
北大核心
2007年第4期729-729,735,共2页
Modern Preventive Medicine
基金
深圳市科技攻关项目(2005276)
