摘要
瘙痒是机体生理状态下自我保护的一种反应机制,也是许多系统性疾病和皮肤疾病的症状之一,目前其产生的具体机制尚不十分清楚。瘙痒有特异的神经传导通路,表明瘙痒和疼痛是不同的独立的感觉形式。近年来的研究发现,传统的瘙痒介质,如组胺、血清素、乙酰胆碱等,通过刺激C类神经纤维产生瘙痒;此外,在皮肤感觉神经纤维也发现有阿片样肽、香草基衍生物等瘙痒介质的受体存在,提示这些介质可能通过与皮肤感觉神经纤维的受体结合介导瘙痒。
Itching is a physiological self-protective mechanism to help defend the skin against harmful external agents. Itch is a major symptom of skin diseases and various systemic diseases and the r exact mechanism of itch is still unknown. The discovery of the itch-specific neuronal pathway, which is distinct from the pain-processing pathway, has clarified the neuronal basis for the itch sensation. That the traditional itch mediators such as histamine, serotonin, or acetylcholine were demonstrated to act pruritogenically on C-fiber. Moreover, new receptor system such as opioid and vanilloid receptors on cutaneous sensory nerve fibers were revealed that may modulate itch and thereby represent targets for antipruritic therapy.
出处
《国际病理科学与临床杂志》
CAS
2006年第6期511-514,共4页
Journal of International Pathology and Clinical Medicine
关键词
瘙痒
皮肤病
介质
itch
dermatosis
mediator
