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PA1-1基因与血栓性疾病

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摘要 纤溶功能下降是多种血栓性疾病的重要发病机制之一,纤溶酶原激活剂抑制物(plasminogen activator inhibitor PAI)约占纤溶系统抑制物活性的60%,PAI-1是其中最重要的成分.自二十世纪八十年代首次发现PAI-1以来,人们对其血浆水平与多种疾病的关系进行了多方面的研究,普遍认为血浆PAI-1水平升高使纤溶功能下降与多种血栓性疾病有显著的关系.二十世纪九十年代,人们对PAI-1基因及其多态性给予更大的关注,本文将对PAI-1基因多态性对血浆PAI-1水平的影响及与冠心病、脑血管病、外周血管血栓的关系进行综述.
作者 路雅茹 秦勤 赵炳让
机构地区 天津胸科医院
出处 《中国分子心脏病学杂志》 CAS 2002年第1期34-38,共5页 Molecular Cardiology of China
关键词 PAI-1基因 血栓性疾病 ACTIVATOR 血浆水平 基因多态性 激活剂抑制物 纤溶功能 抑制物活性
分类号 R543 [医药卫生—心血管疾病]
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参考文献37

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中国分子心脏病学杂志
2002年 第1期

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