摘要
对内科血液病房全年１５１例住院患者进行药物不良反应（ＡＤＲｓ）集中监测，其中１０４例出现４２２次ＡＤＲｓ，发生率为６８．９％（１０４／１５１）。消化系ＡＤＲｓ频率最高（７１．２％）神经系统ＡＤＲｓ其次（３４．６％）。ＡＤＲｓＡ型轻度最多，第１天出现多见。引起ＡＤＲｓ的药物以抗肿瘤药最多，其次为激素类：引起ＡＤＲｓ的单种药共３６种（３１６例次），其中阿糖胞苷居首（１３８例次），其次为强的松；联合用药ＡＤＲｓ共１０６例次。１０４例ＡＲＤｓ组的平均住院日数，用药种数及次数均高于非ＡＤＲｓ组，两组差异均非常显著（Ｐ＜０．０１）。造血系肿瘤及急性白血病患者ＡＤＲｓ发生率最高（９０．９％及８９．８％），红细胞系疾病患者最低（４４．１％）。
An intensive hospital monitoring over a period of one year (Mar.1994 Feb.1995)was perforrned in medical hemoconiosis ward. During the given period 151 hospitalized patients were monitored.There were 422 verified ADRs identified in 104 patients (incident rate=68. 9%).ADRs frequency of the digestive system was the highest(accounted for 71.2%).The second was the nervous system (accounted for 34.6%).The most common manifestation of ADRs was nausea and vomiting(125 times).The second were poor appetide,diarrhea, abdominal ache and superinfection etc.Most ADRs were classified as light degree,type A reactions and appeared in the first day. The most common therapeutic drugs involved were antitumor drugs and hormones. 36 kinds of single drug resulted in ADRs 316 times. The ADRs times of Ara C was the highest (138 times),the second was Prednisone. Combination drug therapy resulted in 106 ADRs times.The ADRs patient group's(n=104) average duration of hospitalization, the number of drug administration, the time of drugs administered were all higher than non - ADRs group's.The differences between two groups were all very significant (P<0.01).Among hemoconiosis diseases the ADRs incident rate of blood forming organs tumor and acute Leukaemia were the highest(90. 9% and 89.8%)and the erythrocyte system disease was the lowest(44.1%).
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1996年第3期172-177,共6页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金
关键词
药物毒副作用
医院监测
血液病房
adverse drug reactions
intensive hospital monitoring
medical hemoconiosis ward
