摘要
我院对609例(60—102岁)内科住院患者进行为期一年的全面药物不良反应监测。609例中166例发生了222次药物不良反应,总发生率为27.26%,女性为39.67%,男性为24.18%,(P<0.01)。呼吸系统疾病与心血管疾病患者ADR发生率偏高、分别为45.12和31.32%。药物中抗感染药物、心血管药物、降糖药和利尿剂等易致ADR,抗生素产生92次ADR,为总数41.44%,2例致急性肾功能衰竭考虑与头孢唑啉有关。91例洋地黄强心甙应用者中有8例产生中毒症状。老年人ADR虽与药物品种有关,但值得重视的是神经精神反应比较常见且易与脑部器质性疾病混淆而误诊。老年人ADR发生偏高的原因显然与生理病理特点有关,脏器功能改变影响药物在体内的过程,此外慢性病多,用药多也是重要原因。ADR监测工作在老年患者中开展的困难更大。现阶段必须依靠医药结合的力量才能逐步提高质量。
Six hundred and nine elderly patients, age 60-102, admittedto the medical wards of Hua Dong Hospital were monitored for adversedrug reactions (ADR) for 1 year. One hundred and sixty six patients werereported to have ADR, the occurrane rate was 27.26% (166/609). Among7589 drug exposures there were 222 reported adverse reactions. Patientssuffering from respiratory and cardiovascular diseases were more susceptible,their incidance was 45. 12% (75/166) and 31.32% (52/166), respectively.Antibiotics, cardiovascular drugs, hypoglycemic and diuretic agents werethe major cause of ADR in this group, e.g. among the 222 ADR, antibioticsaccounted for 92 (41 .44%), of 91 patients given cardiac glycosides 8(8.29%)got toxic manifestations. The clinical manifestations of ADR in the elderlywere varied, CNS manifestation was fairly common and often misdiagnosedas organic brain disease. In summary, higher incidance of ADR in theelderly are a composite of various pathophysiologic characteristics of agingprocess. The increased frequency and number of drug for various chronicdiseases in the elderly patients are also important causal factors.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1989年第2期75-80,共6页
The Chinese Journal of Clinical Pharmacology
关键词
药物不良反应
老年人
药理作用
elderly patients in medical ward
adverse drug reactions monitoring
