摘要
目的探讨炎症标志物与急性冠脉综合征(ACS)的关系及临床意义。方法ELISA测定22例急性心肌梗死(AM I)、37例不稳定型心绞痛(UAP)患者及对照组30例外周血可溶性血管间内皮细胞黏附分子(vascu lar celladhesion molecu le-1,sVCAM-1)和血管性假性血友病因子(von W illebrand Factor,vWF)浓度,所有患者均行冠状动脉造影,记录血管病变情况。结果血清sVCAM-1浓度在AM I组明显高于UAP组及对照组(P<0.01),UAP组明显高于对照组(P<0.01);血浆vWF浓度在AM I组与UAP组均显著高于对照组(P<0.01),但AM I组与UAP组比较无统计学意义;血清sVCAM-1与受累冠状动脉血管支数成正相关,r=0.450,P<0.01。而vWF水平与受累冠状动脉血管支数无相关关系,r=0.074。结论血清sVCAM-1与冠状动脉病变程度密切相关,vWF与ACS的发生发展相关联。
AIM To investigate the relation of inflammation markers to acute coronary syndrome（ACS） and the clinical significance. METHODS The concentrations of serum sVCAM-1 and vWF were assayed by ELISA and the severity of coronary atheroselerosis was evaluated by coronary angiography in 22 patients with acute myocardial infarction （ AMI）, 37 patients with unstable agina pectoris and 30 controls. RESULTS The concentrations of serum sVCAM-1 were significantly higher in ACS patients than those in controls （P 〈0.01 ） and significantly higher in AMI patients than those in UAP patients. The concentrations of serum vWF were significantly higher in ACS patients than those in controls （ P 〈 0.01 ）, but there was no significant difference between the AMI and UAP patients. There was a significant positive correlation between the concentration of serum sVCAM-1 and the lesion extension of coronary artery （r =0.450 P 〈 0.01 ）. CONCLUSION Serum sVCAM-1 levels are correlated with the lesion extension of coronary artery and vWF is a factor in the generation and development of ACS.
出处
《心脏杂志》
CAS
2006年第4期425-426,429,共3页
Chinese Heart Journal
