摘要
目的探索我国艾滋病病毒(HIV)感染者外周血I型干扰素产生细胞(IPC)水平及高效抗逆转录病毒治疗(HAART)对IPC水平的影响。方法采用以BDCA2、BDCA4及CD4作为IPC特征性表面标志组合的全血染色法,对HIV阴性正常人、未接受HAART治疗的HIV感染者、接受3个月以上HAART治疗的HIV感染者的外周血样品IPC水平进行测定,使用SPSS 11.5 for Windows进行数据分析,比较两组间的差异使用Mann-Whitney Test检验。结果HIV感染者外周血中IPC水平明显低于正常人群;病毒载量(VL)低于检测下限(LDL)的感染者其IPC/CD4水平明显高于病毒载量大于LDL的感染人群;有效的HAART治疗后IPC及CD4的数量增加。结论IPC细胞在HIV感染中明显受损,有效的HAART治疗可以部分恢复IPC水平。
Objective To investigate the IPC level in HIV infected individuals and its change during HAART therapy in the Chinese population. Methods A new panel of markers CD4 and BDCA2/BDCA4 were used,which were strictly expressed on IPC by whole blood dyeing and whole white cells gating. IPC numbers in HIV uninfected and infected individuals were analyzed, Data analysis was performed by using SPSS 11.5 for Windows;Mann-Whitney Test was used for comparison between these two groups,Result Compared to the uninfected controls,the Chinese HIV ＋ subjects had significantly lower IPC; the level of IPC was significantly lower in HIV-infected patients with VL〉LDL than in those with VL LDL. IPC levels somewhat recovered during suppressive HAART therapy. Conclusion The IPC level is significantly decreased in HIV-infected patients, and IPC levels can he partially restored during effective HAART therapy,
出处
《中国艾滋病性病》
CAS
2006年第3期193-195,共3页
Chinese Journal of Aids & STD
基金
国家十五科技攻关项目(2004BA719A01)
