摘要
建立了液体顶空气相色谱法测定盐酸马尼地平中有机溶剂残留量。采用 DB-1大口径毛细管柱,以正丙醇为内标进行定量。甲醇、乙醇、异丙醇、乙醚、正丙醇及三氯甲烷的线性范围分别为1．5～61．6μg·mL^(-1)(r=0．9991), 0．4～62．0μg·mL^(-1)(r=0．9994),1．6～64．4μg·mL^(-1)(r=0．9984),1．1～43．6μg·mL^(-1)(r=0．9997)和1．5～63．2μg·mL^(-1)(r=0．9992)；回收率分别为99．9%,103．8%,101．8%,97．7%和98．3%；最低检测限分别为0．02μg·g^(-1),0．04μg·g^(-1),0．02μg·g^(-1), 0．01μg·g^(-1)和0．2μg·g^(-1)。本方法简单、准确、灵敏度及重现性好。
A solution headspace gas chromatography for the determination of residual organic solvent in manidipine Hydrochloride was established. A DB-1 wide bore capillary column was used with 1-propanol as internal standard. The linear range for methanol, ethanol, 2-propanol, ethyl ether and chloroform was 1.5-61.6 μg·mL^-1（r=0.9991）, 0.4-62.0 μg·mL^-1 （r=0.9994）,1.6-64.4 μg·mL^-1 （r=0.9984）, 1.1-43.6 μg·mL^-1 （r=0.9997） and 1.5-63.2 μg·mL^-1（r=0.9992） ,respectively. The average recoveries of methanol, ethanol, 2-propanol, ethyl ether and chloroform were 99.9 %, 103.8 %, 101.8%, 97.7% and 98.3 %,respectively. The lowest test limits of methanol, ethanol, 2-propanol, ethyl ether and chloroform were 0.02 μg·g^-1, 0.04μg·g^-1, 0.02 μg·g^-1, 0.01 μg·g^-1 and 0.2 μg·g^-1,respectively. The method was simple, accurate, sensitive and repeatable.
出处
《生命科学仪器》
2006年第2期37-39,共3页
Life Science Instruments
关键词
液体顶空气相色谱法
大品径毛细管柱
有机溶剂残留
盐酸马尼地平
Solution headspace gas chromatography, Wide bore capillary column, Residual organic solvent, Manidipine hydrochloride.
