摘要
目的了解六类肿瘤患者的免疫状态,探讨T细胞亚群、NK细胞、B细胞绝对数值与肿瘤的相关性。方法采用流式细胞术检测204例肿瘤患者外周血淋巴细胞(T、Th、Ts、NK、B细胞)绝对数值,其中肺癌71例,肝癌39例,鼻咽癌28例,结肠癌29例,乳癌22例,食道癌15例,并与38例正常对照比较。结果与正常对照组比较,肿瘤患者外周血T细胞、Th细胞、Ts细胞、NK细胞绝对数值均降低(P<0.05),B细胞绝对数值无显著差异(P>0.05);各数值在不同肿瘤之间无显著差异(P>0.05)。结论肿瘤患者细胞免疫功能普遍低下,T细胞亚群、NK细胞、B细胞绝对数值可作为肿瘤患者免疫功能的监测指标。
Objective To comprehend the immune status of six groups of tmnor patients, and to discuss the relationship between the development of tumor and the absolute counts change of lymphocyte, which includes T cell subpopulations, NK cell and B cell. Methods The absolute counts including T cell subpopulations, NK cell and B cell were detected with flow cytometry in 204 patients who had 71 cases of lung cancer, 39 cases of liver cancer, 28 cases of nasopharyngeal carcinoma, 29 cases of colon carcinoma, 22 cases of breast cancer, 15 cases of esophageal cancer, and 38 normal controls. Results The absolute counts of T cell subpopulations and NK cell in six groups of tumor patients were lower than that of control group （ P 〈 0.05）, while B cell had no significant difference with control group （ P 〉 0.05）. There were no significant differences among different kinds of tumor patients （ P 〉 0.05）. Conclusion The cellular immunity of tumor patients were commonly low, the absolute counts of lymphocyte in tumor patients may have some action on the occurrence and development of tumor.
出处
《实用肿瘤学杂志》
CAS
2006年第2期81-83,共3页
Practical Oncology Journal
关键词
肿瘤
流式细胞术
淋巴细胞
绝对数值
Tumor
Flow cytometry （FCM）
Lymphocyte
The absolute count
