摘要
2-三氟甲基苯并咪唑-1-乙酰肼在无水乙醇中分别与苯基异硫氰酸酯、对甲苯基异硫氰酸酯、对甲氧苯基异硫氰酸酯和邻甲苯基异硫氰酸酯反应,得到相应的酰氨基硫脲(Ⅲa^d),收率分别为73.3%、87.3%、85.5%和64.3%。再于115~120℃下,与w(NH2NH2.H2O)=85%的水合肼反应4 h,制得3-(2-三氟甲基苯并咪唑-1-亚甲基)-4-氨基-5-芳胺基-1,2,4-三唑(Ⅳa^d),收率分别为53.5%、56.1%、61.8%和50.7%。该方法反应时间短,处理简单,产率较高。目标化合物经元素分析,IR和1HNMR进行了结构确证。
Acyhhiosemicarbazides （ Ⅲa- d ） were prepared by reaction of 2-trifluoromethylbenzimidazole- 1-acetyl hydrazine （ Ⅰ ）with phenyl isothiocyanate,p,methylphenyl isothiocyanate, p-methoxyphenyl isothiocyanate and o-methylphenyl isothiocyanate in the presence of anhydrous ethanol respectively in 73.3% ,87. 3% ,85.5% and 64. 3% yield. Then Ⅲ a-d reacted with 85% hydrazine hydrate at 115 - 120 ℃ for 4h to give 3-（ 2-trifluoromethylbenzimidazole-1-methylene ） -4-amino-5-arylamino-1,2,4- triazole（ Ⅳa-d）, respectively in 53.5% ,56. 1% ,61.8% and 50.7% yield. Advantages of this method is short reaction time, simple reaction process and high yield. Structures of the products were confirmed by elementary analysis, IR and ^1HNMR.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2006年第4期411-413,共3页
Fine Chemicals
