摘要
目的:分析ApoE基因多态性与血脂异常的关系.方法:对高血脂患者72(男46,女26)例,正常对照95(男46,女49)例进行空腹TC,TG,HDL-C,LDL-C检测及ApoE基因型检测.结果:ApoE等位基因频率在两组人群中的分布有相同趋势,等位基因ε3频率最高,血脂正常组为80.5%,血脂异常为76.8%,是我国人群中最常见的等位基因,ε2和ε4相对较少.男女两性间等位基因频率无显著性差异.ApoE基因型与血脂水平有相关性,不论血脂异常或正常,不同基因型间血清TC,LDL-C由低到高依次为ε2/3<ε3/3<ε3/4,HDL-C则相反,为ε3/4<ε3/3<ε2/3.结论:ApoE基因多态性与血脂水平显著相关.
AIM： To evaluate the effects of apolipoprotein E （ApoE） gene polymorphism on the plasma lipid level. METHODS： Seventy-two hypertensive patients （male 46, female 26 ） and 95 healthy controls （ male 46, female 49 ） were examined for their plasma lipid level （TC, TG, HDL-C and LDL-C） and ApoE gene type. RESULTS： The allele frequency distribution was similar between the 2 groups and ε3 allele frequency distribution was the highest, which was 80.5% in normal group and 76.8% in hyperlipemia group, ε2 and ε4 allele frequency distributions were lower than ε3. There was no significant difference between different sexes. ApoE gene type was correlated with serum lipid levels. Serum lipid be normal or not, TC and LDL-C level was ε2/3 〈 ε3/3 〈 ε3/4 and HDL-C was ε3/4 〈ε3/3 〈 ε2/3. CONCLUSION： ApoE gene polymorphism is significantly correlated with serum lipid level.
出处
《第四军医大学学报》
CAS
北大核心
2006年第5期460-461,共2页
Journal of the Fourth Military Medical University
基金
陕西省自然科学基金(2003C208)
