摘要
目的:探讨心力衰竭患者血浆脑钠肽(BNP)的变化及临床意义。方法:测定心力衰竭患者80例及对照组23例空腹血清BNP、左室舒张末内径(LVEDD)、左室射血分数(LVEF)等指标。结果:心力衰竭患者血浆BNP水平显著高于对照组(P<0.01)。心力衰竭组BNP水平随心功能NYHA(美国纽约心脏病学会)分级的加重而增高。心衰患者BNP水平与LVEF呈负相关(r=-0.87,P<0.01),与LVEDD呈正相关(r=0.79,P<0.01)。结论:血浆BNP水平能较好地反映心功能状况,对心衰患者的诊断、病情和预后判断具有重要临床意义。
Objective： To investigate the variation and clinical value of brain natriuretic peptide （BNP） in the patients with heart failure. Methods： The levels of BNP and left ventricular end-diastolic diameter （LVEDD） and left ventricular ejection fraction （LVEF） were tested on the 80 cases of patients with heart failure and 23 cases of control group. Results： The levels of BNP were significantly higher in the patients with heart failure than in control group （P〈0.01）. The levels of BNP in the patients with heart failure were increases with the severity of functional classification （according to New York Heart Association）. The levels of BNP in the patients with heart failure were negatively correlated with LVEF（r=-0.87 ,P〈 0.01 ） and positively correlated with LVEDD （r=0.79,P〈0.01）. Conclusion： The level of BNP can provide useful information in heart function and have important clinical significance in diagnosing and judging severity and prognosis of heart failure.
出处
《海南医学院学报》
CAS
2005年第6期512-514,共3页
Journal of Hainan Medical University
