摘要
目的 观察不同病因心衰患者血浆脑钠素(BNP)水平的变化 ,探讨BNP在心衰发病机制中所起的作用以及 β -受体阻滞剂对心衰患者BNP水平的影响。 方法 采用酶联免疫吸附试验 (ELISA)法测定心衰患者血浆BNP水平。结果 心衰组BNP水平与正常对照组相比显著升高(P <0 0 1)。重度心衰心功能Ⅲ、Ⅳ级BNP水平明显高于心功能Ⅱ级。BNP变化的幅度在冠心病、扩张型心肌病不同病因心衰中有所不同 ,冠心病心衰BNP水平升高更明显 (P <0 0 1)。心衰患者中常规治疗组与非 β -受体阻滞剂治疗组相比 ,美托洛尔和卡维地洛治疗组BNP水平明显降低 (P <0 0 5 )。结论 心衰患者血浆BNP水平显著升高 ,BNP水平与心衰严重程度呈正相关 ,冠心病心衰BNP水平较扩张型心肌病组明显升高 ,提示冠心病心肌缺血损伤可能进一步促进BNP分泌。美托洛尔和卡维地洛均能下调心衰BNP水平 ,可能是不同β -受体阻滞剂逆转心衰神经激素过度激活的共同作用机制之一。
Objectives To study the mechanism of the elevation of BNP in heart failure caused by different heart diseases. Methods The levels of BNP were measured in 112 cases with CHF and 63 normal controls using ELISA test. Results The results showed that the levels plasma of BNP increased significantly in CHF. There was a positive correlation between the levels of plasma BNP and CHF. The levels of BNP were related to the primary disease of CHF. The plasma BNP levels in coronary heart disease (CHD) were significantly higher than in dilated cardiomyopathy (DCM). Conclusions There is a positive correlation between the levels of plasma BNP and CHF. The levels of BNP was related to the primary disease of CHF. The result suggests that BNP may play more important role in CHD than in DCM.
出处
《岭南心血管病杂志》
2004年第6期389-391,共3页
South China Journal of Cardiovascular Diseases
关键词
心力衰竭
血浆脑钠素
Β-受体阻滞剂
发病机制
Heart failure
Congestive
Coronary heart disease
Dilated cardiomyopathy
Brain natriuretic peptide
Metoprolol
Carvedilol
