摘要
目的观察高压氧(HBO)对缺血性脑卒中血浆D-二聚体、纤维蛋白原(Fg)含量的影响。方法选取常规治疗组97例、HBO治疗组137例及正常对照组40例,在入院第2,10,20天对其血浆D-二聚体、Fg水平用STAGO公司血凝仪及配套试剂盒进行检测。结果常规治疗组血浆D-二聚体、Fg水平入院时比正常对照组升高(P<0.01或<0.05);第10天血浆D-二聚体持续升高(P<0.01),Fg水平低于正常对照组(P<0.01);第20天血浆D-二聚体水平下降但仍高于正常对照组(P<0.05),Fg水平恢复正常,与正常对照组差异无统计学意义(P>0.05)。HBO治疗组血浆D-二聚体、Fg水平入院时比对照组升高(P<0.01或<0.05);第10天血浆D-二聚体持续升高(P<0.01)但低于常规治疗组(P<0.05),Fg水平下降但高于正常对照组(P<0.05);第20天血浆D-二聚体、Fg水平与正常对照组差异无统计学意义(P>0.05)。结论HBO能调节D-二聚体、Fg水平,可减轻因缺血、血管损伤引起的凝血、抗凝及纤溶系统异常,对缺血性脑卒中的治疗、预防复发有显著效果。
Objective To observe the effect of hyperbaric oxygen （HBO） on D-dimer（D-D） and fibrinogen（Fg） in the blood plasma of ischemic apoplexy patients. Methods Ischemic apoplexy patients were randomly divided into routine treatment group （97 cases）, HBO treatment group（ 137 cases）,and healthy control group （40 cases） was setup. D-D and Fg in blood plasma were detected by coagulometer of the STAGO Company and its corresponding kit. Results D-D and Fg levels in the blood plasma of the routine treatment group were higher than those of from the control group when hospitalized （ P 〈 0. 01, P 〈 0. 05 ）. D-D kept increasing on the 10 th day after admission（ P 〈0.01 ） ;while Fg was lower than that of the control group（ P 〈0.01 ）. On the 20th day, D-D started to decrease. However, it was still higher than normal level （ P 〈0. 05） ; while Fg becomed normal ,which showed no significant difference from that in the control group （ P 〉0.05 ）. D-D and Fg levels in the blood plasma of the HBO group were higher than those of the control group when hospitalized（ P 〈0. 01 ,P 〈0. 05 ）. D-D kept increasing on the lOth day after admission（ P 〈0.01 ）. However, it was still lower than that of the routine treatment group （ P 〈0. 05 ） ; while Fg started to decrease, but it was higher than normal level（ P 〈0. 05 ）. On the 20th day, D-D and Fg levels showed no significant difference from those of the control group （P 〉 0. 05 ）. Conclusions HBO can relieve coagulation, anticoagulation and abnormal fribrinolysis due to ischemia and damage in the vessels through regulation of D-D and Fg levels in blood plasma, which was effective in preventing treating and ischemic apoplexy.
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2005年第4期246-249,共4页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
基金
南京医科大学科技发展基金资助项目(NY02044)
